Rokicki Wojciech, Rokicki Marek, Wojtacha Jacek, Dżeljijli Agata
Department of Thoracic Surgery, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Poland.
Kardiochir Torakochirurgia Pol. 2016 Mar;13(1):26-30. doi: 10.5114/kitp.2016.58961. Epub 2016 Mar 30.
The report presents the cellular structure of the respiratory system as well as the history of club cells (Clara cells), their ultrastructure, and location in the airways and human organs. The authors discuss the biochemical structure of proteins secreted by these cells and their importance for the integrity and regeneration of the airway epithelium. Their role as progenitor cells for the airway epithelium and their involvement in the biotransformation of toxic xenobiotics introduced into the lungs during breathing is emphasized. This is followed by a discussion of the clinical aspects associated with club cells, demonstrating that tracking the serum concentration of club cell-secreted proteins is helpful in the diagnosis of a number of lung tissue diseases. Finally, suggestions are provided regarding the possible use of proteins secreted by club cells in the treatment of serious respiratory conditions.
该报告介绍了呼吸系统的细胞结构以及克拉拉细胞（俱乐部细胞）的历史、超微结构及其在气道和人体器官中的位置。作者讨论了这些细胞分泌的蛋白质的生化结构及其对气道上皮完整性和再生的重要性。强调了它们作为气道上皮祖细胞的作用以及它们在呼吸过程中引入肺部的有毒外源性物质的生物转化中的参与。随后讨论了与克拉拉细胞相关的临床方面，表明追踪克拉拉细胞分泌蛋白的血清浓度有助于诊断多种肺组织疾病。最后，就克拉拉细胞分泌的蛋白质在治疗严重呼吸道疾病中的可能用途提出了建议。
