Gavrić Aleksandar, Kališnik Jurij Matija
University Medical Center, Ljubljana, Slovenia.
Kardiochir Torakochirurgia Pol. 2016 Mar;13(1):31-8. doi: 10.5114/kitp.2016.58962. Epub 2016 Mar 30.
Acute kidney injury after cardiac surgery with cardiopulmonary bypass is a common and serious complication and it is associated with increased morbidity and mortality. Diagnosis of acute kidney injury is based on the serum creatinine levels which rise several hours to days after the initial injury. Thus, novel biomarkers that will enable faster diagnosis are needed in clinical practice. There are numerous urine and serum proteins that indicate kidney injury and are under extensive research. Despite promising basic research results and assembled data, which indicate superiority of some biomarkers to creatinine, we are still awaiting clinical application.
体外循环心脏手术后发生的急性肾损伤是一种常见且严重的并发症，与发病率和死亡率的增加相关。急性肾损伤的诊断基于血清肌酐水平，其在初始损伤后数小时至数天内升高。因此，临床实践中需要能够实现更快诊断的新型生物标志物。有许多尿液和血清蛋白可指示肾损伤，目前正在进行广泛研究。尽管基础研究结果很有前景且已积累了相关数据，表明某些生物标志物优于肌酐，但我们仍在等待其临床应用。
