GPR55：代谢的帮手还是阻碍？
GPR55: Metabolic Help or Hindrance?
机构信息
Centre for Cognitive and Neural Systems, University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
Screening, Profiling, and Mechanistic Biology, GlaxoSmithKline, Medicines Research Centre, Stevenage SG12NY, UK.
出版信息
Trends Endocrinol Metab. 2016 Sep;27(9):606-608. doi: 10.1016/j.tem.2016.04.012. Epub 2016 May 21.
Since the discovery of the lysophospholipid-sensitive receptor GPR55, hopes have been raised that targeting this G protein-coupled receptor (GPCR) may represent a novel approach for the treatment of metabolic disorders. We discuss conflicting evidence surrounding GPR55 physiology and highlight its potential as a novel target for the treatment of obesity and diabetes.
自从发现溶血磷脂敏感受体 GPR55 以来，人们一直希望靶向这种 G 蛋白偶联受体 (GPCR) 可能代表治疗代谢紊乱的一种新方法。我们讨论了围绕 GPR55 生理学的相互矛盾的证据，并强调了它作为肥胖症和糖尿病治疗新靶点的潜力。
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