Mahony J F, Storey B G, Ibañez R C, Stewart J H
Aust N Z J Med. 1977 Oct;7(5):463-9. doi: 10.1111/j.1445-5994.1977.tb03366.x.
In a consecutive series of 88 cases of carcinoma of the kidney and upper urinary tract seen at one hospital, 31 had malignant urothelial tumours of the renal pelvis or ureter. Forty-two per cent of these transitional-cell carcinomas occurred in patients with renal papillary necrosis following upon prolonged and heavy analgesic ingestion. Other possible aetiological factors were heavy cigarette smoking (61% of cases), long standing urinary obstruction or infection (23%) and possible occupational exposure (6%); in only four cases (13%) was there no identifiable aetiological factor. Those cases with analgesic nephropathy were characterised by renal functional impairment, hypertension and interstitial nephritis, but there was no difference in the clinical behaviour or pathological appearances of the tumours in the two groups. The clinical and experimental evidence that certain metabolites of phenacetin are carcinogenic is reviewed.
在一家医院连续收治的88例肾癌和上尿路癌患者中，31例患有肾盂或输尿管恶性尿路上皮肿瘤。这些移行细胞癌中有42%发生在长期大量服用镇痛药后出现肾乳头坏死的患者中。其他可能的病因包括大量吸烟（61%的病例）、长期尿路梗阻或感染（23%）以及可能的职业暴露（6%）；只有4例（13%）没有可识别的病因。那些患有镇痛药性肾病的病例表现为肾功能损害、高血压和间质性肾炎，但两组肿瘤的临床行为或病理表现并无差异。本文综述了非那西丁某些代谢产物具有致癌性的临床和实验证据。
