S-100a0蛋白刺激与骨骼肌膜相关的基础（镁离子激活的）腺苷酸环化酶活性。

S-100a0 protein stimulates the basal (Mg2+-activated) adenylate cyclase activity associated with skeletal muscle membranes.

作者信息

Fanò G, Angelella P, Mariggiò D, Aisa M C, Giambanco I, Donato R

机构信息

Institute of Cell Biology, Faculty of Sciences, University of Perugia, Italy.

出版信息

FEBS Lett. 1989 May 8;248(1-2):9-12. doi: 10.1016/0014-5793(89)80421-1.

DOI:10.1016/0014-5793(89)80421-1

PMID:2721682

Abstract

S-100a0 protein, the alpha alpha isoform of the S-100 family, stimulates basal (Mg2+-activated) adenylate cyclase (AC) activity associated with the sarcolemma, longitudinal tubules and terminal cisternae of rat skeletal muscle cells. The stimulatory effect of S-100a0 on AC activity is maximal around 5 microM S-100a0 and half-maximal around 0.2 microM S-100a0. Also, the stimulatory effect is greatest on the AC activity associated with the terminal cisternae than on the other membrane fractions studied. These data are discussed in relation to the subcellular localization of S-100a0 in muscle cells.

摘要

S-100a0蛋白是S-100家族的αα亚型，可刺激与大鼠骨骼肌细胞肌膜、纵管和终池相关的基础（Mg2+激活）腺苷酸环化酶（AC）活性。S-100a0对AC活性的刺激作用在约5 microM S-100a0时最大，在约0.2 microM S-100a0时达到半数最大效应。此外，与其他研究的膜组分相比，对与终池相关的AC活性的刺激作用最大。这些数据结合S-100a0在肌肉细胞中的亚细胞定位进行了讨论。