Neonatal metabolic acidosis at birth: In search of a reliable marker.
作者信息
Racinet C, Ouellet P, Charles F, Daboval T
机构信息
UGA Grenoble, Domaine Universitaire, 621, avenue Centrale, 38400 Saint-Martin-d'Hères, France; Childhood Disabilities and Perinatal Data Register (RHEOP), 23, avenue Albert-1(er)-de-Belgique, 38000 Grenoble, France.
Department of Surgery, Sherbrooke University, Sherbrooke, Quebec, Canada; Vitality Health Care Network, zone 4, Edmundston, New Brunswick, Canada.
出版信息
Gynecol Obstet Fertil. 2016 Jun;44(6):357-62. doi: 10.1016/j.gyobfe.2016.04.005. Epub 2016 May 20.
OBJECTIVE
A newborn may present acidemia on the umbilical artery blood which can result from respiratory acidosis or metabolic acidosis or be of mixed origin. Currently, in the absence of a satisfactory definition, the challenge is to determine the most accurate marker for metabolic acidosis, which can be deleterious for the neonate.
METHODS
We reviewed the methodological and physiological aspects of the perinatal literature to search for the best marker of NMA.
RESULTS
Base deficit and pH have been criticized as the standard criteria to predict outcome. The proposed threshold of pathogenicity is not based on convincing studies. The algorithms of various blood gas analyzers differ and do not take into account the specific neonatal acid-base profile.
CONCLUSION
Birth-related neonatal eucapnic pH is described as the most pertinent marker of NMA at birth. The various means of calculating this value and the level below which it seems to play a possible pathogenic role are presented.
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