Pal'chikova N A, Seliatitskaia V G, Arshinova T V, Shorin Iu P
Fiziol Zh (1978). 1989 Mar-Apr;35(2):61-5.
Cold adapted rats are shown to have glucose and fatty acids concentration in blood inchanged, lactate concentration increased and triglyceride concentration decreased against the control level. Glucose utilization rate in the tolerance test grows. Glycogen content falls, hexokinase and succinate dehydrogenase activity increases, glucose-6-phosphatase and NAD+-isocytratedehydrogenase activity decreases in the liver of experimental animals. The results indicate that utilization of carbohydrate and lipid substrates for thermogenesis is intensified in cold-adapted rats. The hypothesis is supported by the data of tests dealing with IPNA injection or with bringing the animals back under thermocomfortable conditions.
结果显示，与对照水平相比，冷适应大鼠血液中的葡萄糖和脂肪酸浓度未发生变化，乳酸浓度升高，甘油三酯浓度降低。在耐受性试验中，葡萄糖利用率提高。实验动物肝脏中的糖原含量下降，己糖激酶和琥珀酸脱氢酶活性增加，葡萄糖-6-磷酸酶和NAD⁺-异柠檬酸脱氢酶活性降低。结果表明，冷适应大鼠利用碳水化合物和脂质底物进行产热的过程增强。对大鼠注射去甲肾上腺素或使其回到热舒适条件下的试验数据支持了这一假说。
