Dudenhausen J W, Hermer M, Rominger K L
Abteilung für Geburtsmedizin der Frauenklinik Berlin-Neukölln, Institut für Perinatale Medizin der Freien Universität Berlin.
Geburtshilfe Frauenheilkd. 1989 Mar;49(3):234-6. doi: 10.1055/s-2008-1035744.
Reports on the clinical effectiveness of oral treatment with beta-sympathomimetic fenoterol are quite divergent in their conclusions. The aim of this study was to determine the plasma levels of fenoterol in steady state during tocolytic treatment with high oral doses. Nine pregnant women with clinically indicated tocolysis were given a 5 mg dose of fenoterol in tablet form eight times per day at prescribed hours. During the first four days, in the late afternoon just before and again one hour after the intake, a blood sample was taken to determine the fenoterol concentration by radioimmunoassay. In addition, uterine activity, blood pressure, heart rate, and tremor were periodically checked while the patient was under observation. The fenoterol levels in the plasma ranged from 130 to 200 pg/ml; the steady state concentration remained relatively constant throughout the observation period. It is not certain, that by taking the blood sample one hour after the tablet was swallowed, the maximal concentration was found. However, with the given doses, nearly the same fenoterol levels were measured in the blood as with low doses of intravenously administered fenoterol.
关于β-拟交感神经药非诺特罗口服治疗临床疗效的报告，其结论差异很大。本研究的目的是确定高剂量口服非诺特罗进行宫缩抑制治疗时的稳态血药浓度。九名有临床指征需要进行宫缩抑制治疗的孕妇，按照规定时间每天八次服用5毫克片剂形式的非诺特罗。在头四天，于每天傍晚服用前及服用后一小时，采集血样，采用放射免疫分析法测定非诺特罗浓度。此外，在观察期间定期检查子宫活动、血压、心率和震颤情况。血浆中非诺特罗水平在130至200皮克/毫升之间；在整个观察期内，稳态浓度保持相对恒定。不确定在吞服片剂一小时后采集血样是否能测得最大浓度。然而，就所给剂量而言，血液中测得的非诺特罗水平与低剂量静脉注射非诺特罗时几乎相同。
