Schöndorf H, Bastert G, Löbel M, Naujoks H
Abteilung Gynäkologie und Geburtshilfe, Ketteler-Krankenhaus Offenbach.
Geburtshilfe Frauenheilkd. 1989 Mar;49(3):272-6. doi: 10.1055/s-2008-1035753.
For better characterisation of the degree of malignancy of breast cancers, we have attempted to establish a correlation between nuclear size and prognosis in breast cancer. Karyometric investigations were carried out on biopsies from 200 primary breast cancers. On the basis of the nuclear areas determined, we were able to distinguish three groups of carcinomas: group I: carcinomas with small nuclear areas (n = 33), mean value 97.76 microns 2, group II: carcinomas with intermediate nuclear areas (n = 98), mean value of the nuclear areas 146.5 microns 2, group III: carcinomas with large nuclear areas (n = 69), mean value 190.8 microns 2. After five years, 6% of the patients in group I had died, as compared to 35% in group II and 48% in group III. The median survival time was 45 to 48 months in group I, as compared to 37 months in group II and 28 months in group III. There was a direct correlation between axillary lymph node status and nuclear size: the carcinomas with the small nuclear sizes showed the least involvement. A comparison of the prognostic relevance of nodal status and nuclear area size, reveals a good relevance for the nuclear area similar to that of the nodal status. The results of the biopsy cytology are already available to the surgeon before the operation.
为了更好地描述乳腺癌的恶性程度，我们试图建立乳腺癌细胞核大小与预后之间的相关性。对200例原发性乳腺癌的活检组织进行了核测量研究。根据所测定的核面积，我们能够区分出三组癌：第一组：核面积小的癌（n = 33），核面积平均值为97.76平方微米；第二组：核面积中等的癌（n = 98），核面积平均值为146.5平方微米；第三组：核面积大的癌（n = 69），核面积平均值为190.8平方微米。五年后，第一组患者中有6%死亡，而第二组为35%，第三组为48%。第一组的中位生存时间为45至48个月，第二组为37个月，第三组为28个月。腋窝淋巴结状态与核大小之间存在直接相关性：核大小小的癌受累最少。对淋巴结状态和核面积大小的预后相关性进行比较，发现核面积与淋巴结状态具有相似的良好相关性。手术前外科医生就能获得活检细胞学的结果。
