Levin G S, Baĭdullaev Sh T, Zhuraleva Zh G, Shubunskaia S S
Gematol Transfuziol. 1989 Jan;34(1):33-7.
The influence of autologous blood, rheopolyglucinum with mannitol and of two combined blood corrigents on tubular secretion (with respect to 131I-hippuran excretion) and glomerular filtration (with the use of 169Yb-DTPA) was studied in experiments on white mice with "irreversible" hemorrhagic shock. It was established that autoblood transfusion led to an insignificant recovery of tubular secretion and glomerular filtration in shock. Rheopolyglucinum with mannitol improved, to some extent, the kidney function, while the combined blood corrigents including rheopolyglucinum, mannitol, crystalloids and sodium succinate contributed to more complete recovery of the kidney function. The highest effect was recorded when the blood corrigent was supplemented by a compound resuming the electron transport along the mitochondrial respiratory chain. The use of the autoblood with combined blood corrigents (1:4) in severe hemorrhagic shock led to the same degree of recovery of tubular secretion and glomerular filtration as combined blood corrigents alone.
在患有“不可逆”失血性休克的白鼠实验中，研究了自体血、含甘露醇的右旋糖酐以及两种复合血液纠正剂对肾小管分泌（根据131I-马尿酸排泄情况）和肾小球滤过（使用169Yb-DTPA）的影响。结果表明，自体血输血使休克状态下的肾小管分泌和肾小球滤过仅有微不足道的恢复。含甘露醇的右旋糖酐在一定程度上改善了肾功能，而包括右旋糖酐、甘露醇、晶体液和琥珀酸钠的复合血液纠正剂则有助于肾功能更完全的恢复。当血液纠正剂补充了一种能恢复线粒体呼吸链电子传递的化合物时，效果最为显著。在严重失血性休克中使用自体血与复合血液纠正剂（1:4），导致肾小管分泌和肾小球滤过的恢复程度与单独使用复合血液纠正剂相同。
