Yang Baiyu, Hagberg Katrina Wilcox, Chen Jie, Sahasrabuddhe Vikrant V, Graubard Barry I, Jick Susan, McGlynn Katherine A
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-9774 USA.
Boston Collaborative Drug Surveillance Program and Boston University School of Public Health, Lexington, MA, 02421 USA.
Br J Cancer. 2016 Jun 28;115(1):85-9. doi: 10.1038/bjc.2016.148. Epub 2016 May 24.
Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans.
We performed a nested case-control study (1195 primary liver cancer cases and 4640 matched controls) within the United Kingdom's Clinical Practice Research Datalink. Antibiotic use was obtained from prescription records. Multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using conditional logistic regression.
Ever-use of prescription antibiotics was associated with a slightly increased risk of liver cancer, compared to non-use (OR=1.22, 95% CI=1.03-1.45). However, there was no clear dose-response relationship by the number of prescriptions or cumulative dose of antibiotic use, suggesting a non-causal association.
Our results do not support a role of antibiotic use in liver cancer development.
使用抗生素可能会改变人类微生物群的组成并降低细菌多样性。这种微生物失调可能与肝癌发生有关;然而,抗生素使用与肝癌风险之间的关联在人类中很少被研究。
我们在英国临床实践研究数据链中进行了一项巢式病例对照研究(1195例原发性肝癌病例和4640例匹配对照)。抗生素使用情况从处方记录中获取。使用条件逻辑回归估计多变量调整后的比值比(OR)和95%置信区间(CI)。
与未使用抗生素相比,曾经使用处方抗生素与肝癌风险略有增加相关(OR=1.22,95%CI=1.03-1.45)。然而,根据处方数量或抗生素使用累积剂量,没有明确的剂量反应关系,提示为非因果关联。
我们的结果不支持抗生素使用在肝癌发生中的作用。