Chen Long Long, Schechtmann Gaston, Ring Patrik, Djurfeldt Diana
Stockholms läns - Psykiatri Nordväst Solna, Sweden Stockholms läns - Psykiatri Nordväst Solna, Sweden.
Neurokirurgiska kliniken, Karolinska sjukhuset - Department of Clinical Neuroscience (CNS), K8 Stockholm, Sweden Neurokirurgiska kliniken, Karolinska sjukhuset - Department of Clinical Neuroscience (CNS), K8 Stockholm, Sweden.
Lakartidningen. 2016 May 19;113:DXMM.
Obsessive-compulsive disorder (OCD), characterized by repetitive intrusive thoughts and ritualized behaviors, is a highly debilitating disorder with an estimated lifetime prevalence of about 2 %. Approximately 10 % of these patients have severe symptoms despite having received all available treatments, thus considered treatment refractory. Deep brain stimulation (DBS), a reversible, safe and adaptive method widely used for movement disorders, enables specific targeting of deep brain structures of relevance in OCD. About 60% of the patients with treatment refractory OCD show ameliorated symptoms and improved quality of life with DBS. Taking ethical aspects into consideration DBS is a viable option for patients with treatment refractory OCD though further studies are needed to fully understand and individualize this treatment.
强迫症（OCD）以反复出现的强迫观念和仪式化行为为特征，是一种极具致残性的疾病，估计终生患病率约为2%。尽管接受了所有可用治疗，但这些患者中约有10%仍有严重症状，因此被认为是难治性的。深部脑刺激（DBS）是一种广泛用于治疗运动障碍的可逆、安全且适应性强的方法，能够特异性地靶向强迫症相关的深部脑结构。约60%的难治性强迫症患者通过DBS症状得到改善，生活质量提高。考虑到伦理方面，DBS对难治性强迫症患者是一种可行的选择，不过还需要进一步研究以充分理解并个体化这种治疗。
