氧化铟锡（ITO）工人的可吸入铟暴露、血浆铟水平与呼吸健康状况
Respirable indium exposures, plasma indium, and respiratory health among indium-tin oxide (ITO) workers.
作者信息
Cummings Kristin J, Virji M Abbas, Park Ji Young, Stanton Marcia L, Edwards Nicole T, Trapnell Bruce C, Carey Brenna, Stefaniak Aleksandr B, Kreiss Kathleen
机构信息
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.
Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea.
出版信息
Am J Ind Med. 2016 Jul;59(7):522-31. doi: 10.1002/ajim.22585. Epub 2016 May 24.
BACKGROUND
Workers manufacturing indium-tin oxide (ITO) are at risk of elevated indium concentration in blood and indium lung disease, but relationships between respirable indium exposures and biomarkers of exposure and disease are unknown.
METHODS
For 87 (93%) current ITO workers, we determined correlations between respirable and plasma indium and evaluated associations between exposures and health outcomes.
RESULTS
Current respirable indium exposure ranged from 0.4 to 108 μg/m(3) and cumulative respirable indium exposure from 0.4 to 923 μg-yr/m(3) . Plasma indium better correlated with cumulative (rs = 0.77) than current exposure (rs = 0.54) overall and with tenure ≥1.9 years. Higher cumulative respirable indium exposures were associated with more dyspnea, lower spirometric parameters, and higher serum biomarkers of lung disease (KL-6 and SP-D), with significant effects starting at 22 μg-yr/m(3) , reached by 46% of participants.
CONCLUSIONS
Plasma indium concentration reflected cumulative respirable indium exposure, which was associated with clinical, functional, and serum biomarkers of lung disease. Am. J. Ind. Med. 59:522-531, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
背景
制造铟锡氧化物（ITO）的工人面临血液中铟浓度升高和患铟肺病的风险，但可吸入铟暴露与暴露及疾病生物标志物之间的关系尚不清楚。
方法
对87名（93%）在职ITO工人，我们测定了可吸入铟与血浆铟之间的相关性，并评估了暴露与健康结果之间的关联。
结果
当前可吸入铟暴露范围为0.4至108μg/m³，累积可吸入铟暴露范围为0.4至923μg-yr/m³。总体而言，血浆铟与累积暴露（rs = 0.77）的相关性优于与当前暴露（rs = 0.54），在任职年限≥1.9年的工人中也是如此。累积可吸入铟暴露量越高，与更多的呼吸困难、更低的肺功能参数以及更高的肺病血清生物标志物（KL-6和SP-D）相关，在22μg-yr/m³时开始出现显著影响，46%的参与者达到此水平。
结论
血浆铟浓度反映了累积可吸入铟暴露，而累积可吸入铟暴露与肺病的临床、功能和血清生物标志物相关。《美国工业医学杂志》59:522 - 531, 2016年。2016年发表。本文为美国政府作品，在美国属于公共领域。
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