Division of Bone Biology, Garvan Institute of Medical Research, 384 Victoria Street, Sydney, New South Wales 2010, Australia.
St Vincent's Clinical School, University of New South Wales Medicine, Sydney, New South Wales 2052, Australia.
Nat Rev Cancer. 2016 May 25;16(6):373-86. doi: 10.1038/nrc.2016.44.
During the past decade preclinical studies have defined many of the mechanisms used by tumours to hijack the skeleton and promote bone metastasis. This has led to the development and widespread clinical use of bone-targeted drugs to prevent skeletal-related events. This understanding has also identified a critical dependency between colonizing tumour cells and the cells of bone. This is particularly important when tumour cells first arrive in bone, adapt to their new microenvironment and enter a long-lived dormant state. In this Review, we discuss the role of different bone cell types in supporting disseminated tumour cell dormancy and reactivation, and highlight the new opportunities this provides for targeting the bone microenvironment to control dormancy and bone metastasis.
在过去的十年中，临床前研究已经确定了肿瘤用于劫持骨骼并促进骨转移的许多机制。这导致了骨靶向药物的开发和广泛的临床应用，以预防与骨骼相关的事件。这种认识还确定了定植肿瘤细胞与骨细胞之间的关键依赖性。当肿瘤细胞首次到达骨骼时，这一点尤其重要，它们需要适应新的微环境并进入长期休眠状态。在这篇综述中，我们讨论了不同类型的骨细胞在支持播散性肿瘤细胞休眠和重新激活中的作用，并强调了这为靶向骨微环境以控制休眠和骨转移提供的新机会。
