Scott Lyne, Li Marilyn, Thobani Salima, Nichols Breck, Morphew Tricia, Kwong Kenny Yat-Choi
a Department of Pediatrics , Division of Allergy-Immunology , Los Angeles County + University of Southern California Medical Center , Los Angeles , CA, USA.
J Asthma. 2016 Aug;53(6):629-34. doi: 10.3109/02770903.2015.1050498. Epub 2016 May 24.
To determine whether significant numbers of asthmatic children with initially rated intermittent asthma later suffer poor asthma control and require the addition of controller medications.
Inner-city Hispanic children were followed prospectively in an asthma-specific disease management system (Breathmobile) for a period of 2 years. Clinical asthma symptoms, morbidity treatment, and demographic data were collected at each visit. Treatment was based upon National Heart, Lung, and Blood Institute (NHLBI) Expert Panel Report 3 asthma guidelines. Primary outcome was percentage of patients with intermittent asthma who had not well or poorly controlled asthma during subsequent visits and required controller agents. Secondary outcomes were factors associated with the maintenance of asthma control.
About 30.9% of the patients with initial rating of intermittent asthma had not well controlled and poorly controlled asthma during subsequent visits and required the addition of controller agents. Factors associated with good asthma control were compliance, no previous emergency room visits and previous visit during spring season.
Asthmatic children with intermittent asthma often lose asthma control and require controller therapy. This justifies asthma guideline recommendations to assess asthma control at follow-up visits and adjust therapy accordingly.
确定大量最初被评定为间歇性哮喘的哮喘儿童日后是否会出现哮喘控制不佳的情况并需要加用控制药物。
对市中心的西班牙裔儿童在一个特定哮喘疾病管理系统(呼吸移动诊所)中进行了为期2年的前瞻性随访。每次就诊时收集临床哮喘症状、发病率治疗情况及人口统计学数据。治疗依据美国国立心肺血液研究所(NHLBI)专家小组报告3哮喘指南进行。主要结局是在后续就诊期间哮喘控制不佳或很差且需要控制药物的间歇性哮喘患者的百分比。次要结局是与维持哮喘控制相关的因素。
约30.9%最初评定为间歇性哮喘的患者在后续就诊期间哮喘控制不佳或很差,需要加用控制药物。与良好哮喘控制相关的因素是依从性、既往无急诊就诊史以及春季就诊。
患有间歇性哮喘的哮喘儿童常出现哮喘控制不佳的情况,需要控制治疗。这证明了哮喘指南中关于在随访时评估哮喘控制情况并相应调整治疗的建议是合理的。