Blood Cell Development and Function Program, Institute for Cancer Research, Fox Chase Cancer Center (FCCC), Philadelphia, PA 19111, USA.
Sci Signal. 2016 May 24;9(429):fs8. doi: 10.1126/scisignal.aaf6348.
Natural killer (NK) cells are innate lymphoid cells that have adopted activating and inhibitory signaling mechanisms enabling them to be tolerant of normal cells but to distinguish and eliminate tumor cells and virus-infected cells. In this issue of Science Signaling, Matalon et al show how inhibitory receptors disrupt NK cell activation by stimulating dephosphorylation of the adaptor protein LAT (linker of activated T cells) and phospholipase C-γ by the phosphatase SHP-1 [Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 1], as well as ubiquitylation of LAT by Cbl family E3 ubiquitin ligases.
自然杀伤 (NK) 细胞是先天淋巴细胞,它们采用了激活和抑制信号机制,使它们能够耐受正常细胞,但能够区分和消除肿瘤细胞和病毒感染的细胞。在本期《科学信号》中,Matalon 等人展示了抑制性受体如何通过刺激磷酸酶 SHP-1(Src 同源 2 (SH2) 结构域含蛋白酪氨酸磷酸酶 1)使衔接蛋白 LAT(激活的 T 细胞连接蛋白)和磷脂酶 C-γ去磷酸化,以及 Cbl 家族 E3 泛素连接酶使 LAT 泛素化,从而破坏 NK 细胞的激活。