Alrashidy Mohammed, Atef Aliaa, Baky Tarek Abdel
Department of Pathology, Faculty of Medicine, University of Tanta, Tanta, Egypt E-mail :
Asian Pac J Cancer Prev. 2016;17(4):1769-72. doi: 10.7314/apjcp.2016.17.4.1769.
Urothelial papilloma and non-invasive papillary carcinoma are common neoplasms of the urinary bladder. Distinguishing papillomas and papillary carcinomas, especially the low grade type, is often debatable on the basis of histological features alone.
We investigated immunohistochemical expression of cytokeratin 20 (CK20), p53, and Ki-67 in a group of 20 urothelial papilloma cases and 30 noninvasive papillary neoplasms of low malignant potential (PNLMP) of the urinary bladder. Whole tissue sections were examined.
Among the 30 carcinoma cases, 12 (40%) showed strong reactivity for the whole panel, 16 (53%) reacted positively for two markers, and 2 (7%) reacted just to one of them. Ki-67 was considered positive in 27 cases (90%) and p53 in 24 (80%), CK20 showed positive reactivity in 21 cases (70%). Only small percentages of papillomas were positive, and then only weakly.
We concluded that the intense positivity of suspicious cells for at least one of these markers would confirm the presence of malignant changes and favours the diagnosis of carcinoma.
尿路上皮乳头状瘤和非浸润性乳头状癌是膀胱常见的肿瘤。仅根据组织学特征区分乳头状瘤和乳头状癌，尤其是低级别类型，往往存在争议。
我们研究了20例尿路上皮乳头状瘤病例和30例膀胱低恶性潜能非浸润性乳头状肿瘤（PNLMP）中细胞角蛋白20（CK20）、p53和Ki-67的免疫组化表达。对全组织切片进行检查。
在30例癌病例中，12例（40%）对全部标记物呈强反应性，16例（53%）对两种标记物呈阳性反应，2例（7%）仅对其中一种呈阳性反应。Ki-67在27例（90%）中被认为呈阳性，p53在24例（80%）中呈阳性，CK20在21例（70%）中呈阳性反应。只有小部分乳头状瘤呈阳性，且反应较弱。
我们得出结论，可疑细胞对这些标记物中至少一种呈强阳性将证实存在恶性改变，有助于癌的诊断。
