• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Budesonide reduces sensitivity to antigen but does not alter baseline tone or responsiveness to carbachol, terbutaline, and enprofylline in IgE-sensitized guinea-pig tracheae.

作者信息

Persson C G, Andersson P T, Gustafsson B

机构信息

Department of Clinical Pharmacology, University Hospital of Lund, Sweden.

出版信息

Int Arch Allergy Appl Immunol. 1989;88(4):381-5. doi: 10.1159/000234721.

DOI:10.1159/000234721
PMID:2722258
Abstract

In vitro incubation of IgE-sensitized guinea-pig tracheal rings with 10(-7) M budesonide for 24 h significantly shifted the concentration-response curve to antigen by 5-fold to the right. Smooth muscle characteristics such as baseline tone, muscarinic contraction or relaxation to beta 2-receptor agonists and xanthines were not or only marginally affected by this exposure of airway tissue to a glucocorticoid drug. It is concluded that budesonide reduced anaphylactic IgE-driven release of contractile mediators.

摘要

相似文献

1
Budesonide reduces sensitivity to antigen but does not alter baseline tone or responsiveness to carbachol, terbutaline, and enprofylline in IgE-sensitized guinea-pig tracheae.
Int Arch Allergy Appl Immunol. 1989;88(4):381-5. doi: 10.1159/000234721.
2
Effect of three weeks' treatment with budesonide on in vitro contractile and relaxant airway effects in the rat.布地奈德三周治疗对大鼠气道体外收缩和舒张作用的影响。
Thorax. 1989 Jan;44(1):24-7. doi: 10.1136/thx.44.1.24.
3
Protective effects of the glucocorticoid, budesonide, on lung anaphylaxis in actively sensitized guinea-pigs: inhibition of IgE-but not of IgG-mediated anaphylaxis.糖皮质激素布地奈德对主动致敏豚鼠肺部过敏反应的保护作用：抑制IgE介导而非IgG介导的过敏反应。
Br J Pharmacol. 1982 May;76(1):139-47. doi: 10.1111/j.1476-5381.1982.tb09199.x.
4
Effect of different bronchodilators on airway smooth muscle responsiveness to contractile agents.不同支气管扩张剂对气道平滑肌对收缩剂反应性的影响。
Thorax. 1991 May;46(5):360-5. doi: 10.1136/thx.46.5.360.
5
Parainfluenza 3 infection blocks the ability of a beta adrenergic receptor agonist to inhibit antigen-induced contraction of guinea pig isolated airway smooth muscle.副流感病毒3型感染会阻断β肾上腺素能受体激动剂抑制抗原诱导的豚鼠离体气道平滑肌收缩的能力。
J Clin Invest. 1981 Feb;67(2):376-84. doi: 10.1172/JCI110045.
6
The relaxant effect of ketamine on guinea pig airway smooth muscle is epithelium-independent.氯胺酮对豚鼠气道平滑肌的舒张作用不依赖于上皮。
Anesth Analg. 1997 Mar;84(3):641-7. doi: 10.1097/00000539-199703000-00033.
7
Increased cholinergic antagonism underlies impaired beta-adrenergic response in ovalbumin-sensitized guinea pigs.胆碱能拮抗作用增强是卵清蛋白致敏豚鼠β-肾上腺素能反应受损的基础。
J Appl Physiol (1985). 1993 Jun;74(6):2729-35. doi: 10.1152/jappl.1993.74.6.2729.
8
Sensitization does not alter phasic and tonic responses to carbachol in isolated epithelium-free guinea-pig trachea.致敏作用不会改变离体无上皮豚鼠气管对卡巴胆碱的相位性和紧张性反应。
Life Sci. 1991;49(12):907-13. doi: 10.1016/0024-3205(91)90176-c.
9
Actions and interactions of adenosine, theophylline and enprofylline on the guinea-pig spirally cut trachea.腺苷、茶碱和恩丙茶碱对豚鼠螺旋形切片气管的作用及相互作用
Eur J Pharmacol. 1986 Jun 24;125(3):353-62. doi: 10.1016/0014-2999(86)90791-0.
10
IgG vs IgE: mediators of antigen-induced guinea pig tracheal contraction.免疫球蛋白G与免疫球蛋白E：抗原诱导豚鼠气管收缩的介质
Immunopharmacology. 1984 Dec;8(3-4):111-9. doi: 10.1016/0162-3109(84)90014-6.