Forat-Yazdi M, Hosseini-Biouki F, Salehi J, Neamatzadeh H, Masoumi Dehshiri R, Sadri Z, Ghanizadeh F, Sheikhpour R, Zare-Zardini H
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Iran J Ped Hematol Oncol. 2016;6(1):52-63. Epub 2016 Mar 15.
Evidence indicates RFC1 G80A polymorphism as a risk factor for a number of cancers. Increasing studies have been conducted on the association of RFC1 G80A polymorphism with acute lymphoblastic leukemia (ALL) risk. However, the results were controversial. The aim of the present study was to derive a more precise estimation of the relationship.
PubMed, Embase, Web of Science, Cochrane database, and Google Scholar were searched to get the genetic association studies between RFC1 G80A polymorphism and ALL. All eligible studies for the period up to February 2016 were identified. Subgroup analyses regarding ethnicity were also implemented. All statistical analyses were done with CMA 2.0.
A total of ten studies comprising of 2,168 ALL cases and 2,693 healthy controls were included in this meta-analysis. Overall, no significant association was detected for allelic model (OR = 1.029, 95 % CI 0.754- 1.405, P=0.000), Dominant model (OR = 1.619, 95 % CI 0.847-3.094, P=0.145), recessive model (OR = 1.169, 95 % CI 10.764-1.790, P=0.429), and homozygote model (OR = 1.288, 95 % CI 0.928-1.788, P=0.130). However, there was an obvious association under the heterozygote model (OR = 1.368, 95 % CI 1.056- 1.772, P=0.018). Also, in the stratified analysis by ethnicity, no significant association of this polymorphism with risk of OC was found in the Asian and Caucasian populations. However, there was not significant heterogeneity between heterozygote genetic model (P = 0.15, I(2) = 33%) in Caucasian. Therefore, we utilized the fixed-effect model to merge OR value.
Based on the available evidence, no association between RFC1 G80A Polymorphism and ALL risk was observed, even in the subanalysis by ethnicity. The direction of further research should focus not only on the simple relationship of RFC1 G80A Polymorphism and ALL risk, but also on gene-gene and gene-environment interaction.
有证据表明RFC1 G80A基因多态性是多种癌症的风险因素。关于RFC1 G80A基因多态性与急性淋巴细胞白血病（ALL）风险的关联，已有越来越多的研究。然而，结果存在争议。本研究的目的是更精确地评估两者之间的关系。
检索了PubMed、Embase、Web of Science、Cochrane数据库和谷歌学术，以获取RFC1 G80A基因多态性与ALL之间的基因关联研究。确定了截至2016年2月的所有符合条件的研究。还进行了种族亚组分析。所有统计分析均使用CMA 2.0完成。
本荟萃分析共纳入10项研究，包括2168例ALL病例和2693例健康对照。总体而言，在等位基因模型（OR = 1.029，95%CI 0.754 - 1.405，P = 0.000）、显性模型（OR = 1.619，95%CI 0.847 - 3.094，P = 0.145）、隐性模型（OR = 1.169，95%CI 10.764 - 1.790，P = 0.429）和纯合子模型（OR = 1.288，95%CI 0.928 - 1.788，P = 0.130）中均未检测到显著关联。然而，在杂合子模型下存在明显关联（OR = 1.368，95%CI 1.056 - 1.772，P = 0.018）。此外，在按种族进行的分层分析中，在亚洲和白种人群中未发现该基因多态性与ALL风险有显著关联。然而，白种人中杂合子遗传模型之间不存在显著异质性（P = 0.15，I² = 33%）。因此，我们使用固定效应模型合并OR值。
基于现有证据，未观察到RFC1 G80A基因多态性与ALL风险之间存在关联，即使在按种族进行的亚分析中也是如此。进一步研究的方向不仅应关注RFC1 G80A基因多态性与ALL风险的简单关系，还应关注基因 - 基因和基因 - 环境相互作用。
