Aghasipour Maryam, Asadian Fatemeh, Dastgheib Seyed Alireza, Alijanpour Abolhasan, Masoudi Ali, Barahman Maedeh, Golshan-Tafti Mohammad, Bahrami Reza, Shiri Amirmasoud, Aarafi Hossein, Aghili Kazem, Neamatzadeh Hossein
College of Medicine, University of Cincinnati, Ohio, USA.
School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran.
Hematol Transfus Cell Ther. 2024 Dec;46 Suppl 6(Suppl 6):S332-S345. doi: 10.1016/j.htct.2024.05.017. Epub 2024 Oct 8.
Acute lymphoblastic leukemia is the predominant neoplastic ailment in childhood. Prior research has already established noteworthy connections between CDKN2A polymorphisms and susceptibility to this childhood leukemia, however, substantial associations are still awaiting validation. This investigation was undertaken to examine the correlation between CDKN2A polymorphisms and the risk of acute lymphoblastic leukemia in children.
Acquisition of information encompassed the exploration of diverse databases including PubMed, Scopus, EMBASE, and China National Knowledge Infrastructure (CNKI) until January 10, 2024. An estimation of associations was achieved utilizing odds ratios with 95% confidence intervals.
A total of 22 case-control studies encompassing 10,203 cases of acute lymphoblastic leukemia and 36,424 healthy controls were included. Within this pool of studies, 14 focused on rs3731217, comprising 5396 cases and 15,787 controls, whereas eight studies investigated rs3731249, comprising 4807 cases and 20,637 controls. The aggregated data showed that the rs3731217 variant offers protection against acute lymphoblastic leukemia. Nevertheless, when subgroups are analyzed according to ethnicity, it becomes clear that the rs3731217 polymorphism significantly influences susceptibility, particularly among individuals of Caucasian and African descent with no such association being observed in children of Asian origin. Nevertheless, the rs3731249 polymorphism displayed a noteworthy correlation with vulnerability to pediatric acute lymphoblastic leukemia.
The aggregated data revealed that the rs3731217 variation offers protection against the development of pediatric acute lymphoblastic leukemia and the rs3731249 polymorphism is significantly correlated with susceptibility.
急性淋巴细胞白血病是儿童期主要的肿瘤性疾病。先前的研究已经在CDKN2A基因多态性与儿童白血病易感性之间建立了显著联系，然而，大量关联仍有待验证。本研究旨在探讨CDKN2A基因多态性与儿童急性淋巴细胞白血病风险之间的相关性。
信息获取包括检索多个数据库，如PubMed、Scopus、EMBASE和中国知网（CNKI），检索截至2024年1月10日的文献。利用比值比及95%置信区间评估关联性。
共纳入22项病例对照研究，包括10203例急性淋巴细胞白血病病例和36424例健康对照。在这些研究中，14项聚焦于rs3731217，包括5396例病例和15787例对照，而8项研究调查了rs3731249，包括4807例病例和20637例对照。汇总数据显示，rs3731217变异对急性淋巴细胞白血病具有保护作用。然而，按种族进行亚组分析时，很明显rs3731217多态性显著影响易感性，尤其是在白种人和非洲裔个体中，而在亚洲裔儿童中未观察到这种关联。然而，rs3731249多态性与儿童急性淋巴细胞白血病易感性显著相关。
汇总数据显示，rs3731217变异对儿童急性淋巴细胞白血病的发生具有保护作用，且rs3731249多态性与易感性显著相关。
