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1例采用全身糖皮质激素治疗的重症急性外源性类脂性肺炎

A severe case of acute exogenous lipoid pneumonia treated with systemic corticosteroid.

作者信息

Yasui Hideki, Yokomura Koshi, Suda Takafumi

机构信息

Department of Respiratory Medicine, Seirei Mikatahara General Hospital, Hamamatsu, Japan; Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Department of Respiratory Medicine, Seirei Mikatahara General Hospital, Hamamatsu, Japan.

出版信息

Respir Med Case Rep. 2016 Jan 25;17:64-7. doi: 10.1016/j.rmcr.2016.01.009. eCollection 2016.

Abstract

Acute exogenous lipoid pneumonia is a rare disorder in adults. A treatment of choice for lipoid pneumonia has not been established, and systemic corticosteroid use remains controversial. We report the case of a 32-year-old man with schizophrenia who presented with kerosene-induced acute exogenous lipoid pneumonia that was treated with a systemic corticosteroid. In this case, supportive therapy did not improve the patient's condition, so systemic corticosteroid therapy was commenced four days after he ingested the kerosene. After corticosteroid commencement, the patient's symptoms and hypoxia improved within a few days. Although some radiological characteristics of this disorder have been reported previously, the process of radiological improvement of exogenous lipoid pneumonia is not well known. In this case, computed tomography findings changed dramatically after corticosteroid therapy was initiated. Extensive bilateral consolidations that were observed on admission improved. Although pneumatoceles developed two weeks after corticosteroid commencement, they were nearly gone after two months of the treatment. While corticosteroid therapy is not suitable for all cases, it should be considered for severe or refractory cases.

摘要

急性外源性类脂性肺炎在成人中是一种罕见疾病。类脂性肺炎的首选治疗方法尚未确定,全身使用皮质类固醇仍存在争议。我们报告一例32岁精神分裂症男性患者,其因煤油导致急性外源性类脂性肺炎,并接受了全身皮质类固醇治疗。在此病例中,支持治疗未能改善患者病情,因此在他摄入煤油四天后开始全身皮质类固醇治疗。开始使用皮质类固醇后,患者症状和缺氧情况在数天内得到改善。虽然此前已报道过该疾病的一些影像学特征,但外源性类脂性肺炎的影像学改善过程尚不为人所知。在此病例中,计算机断层扫描结果在开始皮质类固醇治疗后发生了显著变化。入院时观察到的广泛双侧实变有所改善。虽然在开始使用皮质类固醇两周后出现了肺气囊,但在治疗两个月后几乎消失。虽然皮质类固醇治疗并非适用于所有病例,但对于重症或难治性病例应予以考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d19/4821340/55114fdd6081/gr1.jpg

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