微小RNA在人乳头瘤病毒阴性扁桃体癌中的表达及其对程序性细胞死亡蛋白4的调控

Expression of microRNAs in HPV negative tonsil cancers and their regulation of PDCD4.

作者信息

Khoury Samantha, Ahadi Alireza, Zhang Xiaoying, Tran Nham

机构信息

Centre for Health Technologies, Faculty of Engineering and Information Technology, University of Technology, Sydney, Australia.

The Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, Australia; Department of Infectious Diseases and Immunology, University of Sydney, NSW, Australia.

出版信息

Genom Data. 2016 Apr 18;8:93-6. doi: 10.1016/j.gdata.2016.04.007. eCollection 2016 Jun.

DOI:10.1016/j.gdata.2016.04.007

PMID:27222808

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4856814/

Abstract

Global rates of tonsil cancer have been increasing since the turn of the millennia, however we still have a limited understanding of the genes and pathways which control this disease. This array dataset which is linked to our publication (Zhang et al., 2015) describes the profiling of human miRNAs in tonsil and normal adjacent tissues. With this dataset, we identified a list of microRNA (miRNA) which were highly over represented in tonsil cancers and showed that several miRNAs were able to regulate the tumour suppressor PDCD4 in a temporal manner. The dataset has been deposited into Gene Expression Omnibus (GSE75630).

摘要

自千禧年之交以来，全球扁桃体癌发病率一直在上升，然而我们对控制这种疾病的基因和信号通路仍了解有限。这个与我们的出版物（Zhang等人，2015年）相关的阵列数据集描述了人类扁桃体和相邻正常组织中微小RNA（miRNA）的分析情况。通过这个数据集，我们确定了一系列在扁桃体癌中高度富集的微小RNA（miRNA），并表明几种miRNA能够以时间依赖性方式调节肿瘤抑制因子PDCD4。该数据集已存入基因表达综合数据库（GSE75630）。