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结核疹:年轻患者中结核分枝杆菌感染的皮肤指示性疾病。

Tuberculids: cutaneous indicator diseases of Mycobacterium tuberculosis infection in young patients.

作者信息

Hallensleben N D L, de Vries H J C, Lettinga K D, Scherpbier H J

机构信息

Emma Childrens' Hospital, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

Department of Dermatology, Academic Medical Centre, Amsterdam, The Netherlands.

出版信息

J Eur Acad Dermatol Venereol. 2016 Sep;30(9):1590-3. doi: 10.1111/jdv.13723. Epub 2016 May 26.

Abstract

BACKGROUND

In the past years the incidence of tuberculosis has dropped significantly in most parts of Europe and the presentation of symptomatic tuberculosis cases have become increasingly rare. With the recent influx of refugees in Europe coming from tuberculosis endemic areas like the Middle East and Africa, it is expected that the incidence of tuberculosis will increase.

OBJECTIVES

Cutaneous symptoms are important hallmarks that can be of aid for the correct diagnosis of an underlying disease, like tuberculosis.

METHODS

We describe 2 young patients with tuberculids, respectively lichen scrofulosorum and papulonecrotic tuberculids, caused by a systemic Mycobacterium tuberculosis infection.

RESULTS

Tuberculids are cutaneous immunological reactions triggered by a Mycobacterium tuberculosis infection elsewhere in the body. The three main manifestations of cutaneous tuberculids are: lichen scrofulosorum, papulonecrotic tuberculids and erythema induratum of Bazin. Whereas the latter is more common, the first two presentations are rare.

CONCLUSION

It is of importance that clinicians, including dermatologists, are aware of the spectrum of clinical presentations of tuberculosis to halt this destructive and highly contagious disease early in its course.

摘要

背景

在过去几年中,欧洲大部分地区的结核病发病率显著下降,有症状的结核病病例越来越少见。随着近期来自中东和非洲等结核病流行地区的难民涌入欧洲,预计结核病发病率将会上升。

目的

皮肤症状是重要的特征,有助于正确诊断潜在疾病,如结核病。

方法

我们描述了2例结核疹患者,分别为瘰疬性苔藓和丘疹坏死性结核疹,由全身性结核分枝杆菌感染引起。

结果

结核疹是由身体其他部位的结核分枝杆菌感染引发的皮肤免疫反应。皮肤结核疹的三种主要表现为:瘰疬性苔藓、丘疹坏死性结核疹和巴赞硬红斑。虽然后者更常见,但前两种表现较为罕见。

结论

包括皮肤科医生在内的临床医生了解结核病的临床表现范围很重要,以便在病程早期阻止这种具有破坏性和高度传染性的疾病。

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