Liedes Hilkka, Mattila Jussi, Lingsma Hester, Lötjönen Jyrki, Menon David, Tenovuo Olli, van Gils Mark
VTT Technical Research Centre of Finland Ltd, Tampere, Finland.
Erasmus Medical Centre, Rotterdam, The Netherlands.
Stud Health Technol Inform. 2016;224:175-80.
Traumatic brain injury (TBI) is a major cause of death and disability, especially in young adults. A reliable prediction of outcome after TBI is of great importance in clinical practice and research. We aimed to compare performance of the well-established IMPACT calculator and an alternative method, Disease State Index (DSI), in the prediction of six-month outcome after TBI. Performance of the models was evaluated using 2036 patients with moderate or severe TBI from the International Mission for Prognosis and Analysis of Clinical Trials in TBI (IMPACT) database. Prediction performance of both models was similar. The models with more variables provided better performance than the simpler models. This study showed that the DSI is a valid tool with efficient visualizations that can help clinicians with their decision making process in clinical practice.
创伤性脑损伤（TBI）是死亡和残疾的主要原因，尤其是在年轻人中。在临床实践和研究中，对TBI后结果进行可靠预测非常重要。我们旨在比较成熟的IMPACT计算器和另一种方法疾病状态指数（DSI）在预测TBI后六个月结果方面的表现。使用来自创伤性脑损伤临床试验国际预后与分析任务组（IMPACT）数据库的2036例中度或重度TBI患者评估模型的表现。两种模型的预测表现相似。变量更多的模型比更简单的模型表现更好。这项研究表明，DSI是一种有效的工具，具有高效的可视化功能，可帮助临床医生在临床实践中进行决策。
