Dresser R
School of Law, Case Western Reserve University, Cleveland, OH 44106.
J Am Vet Med Assoc. 1989 May 1;194(9):1184-91.
Thirty-two institutional animal care and use committees reviewed 4 hypothetic protocols involving experimental procedures frequently conducted on animals. Committees were in general agreement on the need to refine hypothetic protocols to minimize pain, distress, and other harm to laboratory animals. All but 2 committees sought modifications in each protocol, and in numerous instances, committees would not approve a protocol without major modifications. The committee responses delineated emerging standards governing specific areas of animal use, such as antibody production, induced disease, surgery, physical restraint, and behavioral conditioning. Committees had less consensus in their approach to assessing the justification for laboratory animal use. Apparently, this component of committee responsibilities presented the major conceptual and practical difficulties for committees engaged in animal research review.
32个机构动物护理和使用委员会审查了4个假设方案，这些方案涉及经常在动物身上进行的实验程序。委员会普遍同意需要完善假设方案，以尽量减少对实验动物的疼痛、痛苦和其他伤害。除了2个委员会外，其他所有委员会都寻求对每个方案进行修改，而且在很多情况下，如果不进行重大修改，委员会就不会批准某个方案。委员会的回应勾勒出了适用于动物使用特定领域的新出现的标准，如抗体生产、诱发疾病、手术、身体约束和行为条件作用。委员会在评估实验动物使用合理性的方法上共识较少。显然，委员会职责的这一部分给从事动物研究审查的委员会带来了主要的概念和实际困难。
