• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

长期热适应靶向谷氨酸受体能否改善缺氧损伤后的预后？

Can targeting glutamate receptors with long-term heat acclimation improve outcomes following hypoxic injury?

作者信息

Ely Brett R, Brunt Vienna E, Minson Christopher T

机构信息

Department of Human Physiology; University of Oregon ; Eugene, OR USA.

出版信息

Temperature (Austin). 2015 Feb 3;2(1):51-2. doi: 10.4161/23328940.2014.992657. eCollection 2015 Jan-Mar.

DOI:10.4161/23328940.2014.992657
PMID:27227003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4843862/
Abstract

Long-term heat acclimation appears to improve tolerance to hypoxic insults in various tissues, including brain, providing a promising avenue to improve functional outcomes following cerebrovascular events. Glutamate discharge is implicated in dysfunction following hypoxic stress and thus, targeting glutamate receptors with heat acclimation could improve cognitive outcomes following hypoxic injury.

摘要

长期热适应似乎能提高包括大脑在内的各种组织对缺氧损伤的耐受性，为改善脑血管事件后的功能结局提供了一条有前景的途径。谷氨酸释放与缺氧应激后的功能障碍有关，因此，通过热适应靶向谷氨酸受体可能会改善缺氧损伤后的认知结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfb2/4843862/7dba715c775f/ktmp-02-01-992657-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfb2/4843862/7dba715c775f/ktmp-02-01-992657-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfb2/4843862/7dba715c775f/ktmp-02-01-992657-g001.jpg

相似文献

1
Can targeting glutamate receptors with long-term heat acclimation improve outcomes following hypoxic injury?长期热适应靶向谷氨酸受体能否改善缺氧损伤后的预后？
Temperature (Austin). 2015 Feb 3;2(1):51-2. doi: 10.4161/23328940.2014.992657. eCollection 2015 Jan-Mar.
2
The protective effect of heat acclimation from hypoxic damage in the brain involves changes in the expression of glutamate receptors.热适应对大脑缺氧损伤的保护作用涉及谷氨酸受体表达的变化。
Temperature (Austin). 2014 Jul 1;1(1):57-65. doi: 10.4161/temp.29719. eCollection 2014 Apr-Jun.
3
Molecular programs induced by heat acclimation confer neuroprotection against TBI and hypoxic insults via cross-tolerance mechanisms.热适应诱导的分子程序通过交叉耐受机制赋予对创伤性脑损伤和缺氧性损伤的神经保护作用。
Front Neurosci. 2015 Jul 28;9:256. doi: 10.3389/fnins.2015.00256. eCollection 2015.
4
Heat and Hypoxic Acclimation Increase Monocyte Heat Shock Protein 72 but Do Not Attenuate Inflammation following Hypoxic Exercise.热适应和低氧适应可增加单核细胞热休克蛋白72，但不能减轻低氧运动后的炎症反应。
Front Physiol. 2017 Oct 16;8:811. doi: 10.3389/fphys.2017.00811. eCollection 2017.
5
Cross Acclimation between Heat and Hypoxia: Heat Acclimation Improves Cellular Tolerance and Exercise Performance in Acute Normobaric Hypoxia.热与低氧之间的交叉适应：热适应可提高急性常压低氧下的细胞耐受性和运动表现。
Front Physiol. 2016 Mar 8;7:78. doi: 10.3389/fphys.2016.00078. eCollection 2016.
6
Heat acclimation and cross tolerance to hypoxia: Bridging the gap between cellular and systemic responses.热适应与对缺氧的交叉耐受性：弥合细胞反应与全身反应之间的差距。
Temperature (Austin). 2014 Jul 8;1(2):107-14. doi: 10.4161/temp.29800. eCollection 2014 Jul-Sep.
7
Heat acclimation and performance in hypoxic conditions.热适应与低氧条件下的表现
Aviat Space Environ Med. 2012 Jul;83(7):649-53. doi: 10.3357/asem.3241.2012.
8
Human monocyte heat shock protein 72 responses to acute hypoxic exercise after 3 days of exercise heat acclimation.运动热适应3天后，人体单核细胞热休克蛋白72对急性低氧运动的反应。
Biomed Res Int. 2015;2015:849809. doi: 10.1155/2015/849809. Epub 2015 Mar 22.
9
No ergogenic effects of a 10-day combined heat and hypoxic acclimation on aerobic performance in normoxic thermoneutral or hot conditions.10 天联合热和低氧习服对常氧热中性或热环境下有氧运动能力无增效作用。
Eur J Appl Physiol. 2019 Dec;119(11-12):2513-2527. doi: 10.1007/s00421-019-04215-5. Epub 2019 Sep 25.
10
HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart.缺氧诱导因子-1α靶向通路通过热适应被激活，并有助于心脏的适应-缺血交叉耐受。
Physiol Genomics. 2005 Sep 21;23(1):79-88. doi: 10.1152/physiolgenomics.00279.2004. Epub 2005 Jul 26.

引用本文的文献

1
Brain diseases in changing climate.气候变化相关的脑部疾病
Environ Res. 2019 Oct;177:108637. doi: 10.1016/j.envres.2019.108637. Epub 2019 Aug 8.
2
A Valentine's Day bouquet for Temperature readers: pleasing with prizes, searching for the right words, and keeping things mysterious.给《温度》读者们的情人节花束：用奖品取悦读者、寻找恰当的措辞以及让事情保持神秘。
Temperature (Austin). 2015 Mar 12;2(1):17-21. doi: 10.1080/23328940.2015.1017089. eCollection 2015 Jan-Mar.

本文引用的文献

1
The protective effect of heat acclimation from hypoxic damage in the brain involves changes in the expression of glutamate receptors.热适应对大脑缺氧损伤的保护作用涉及谷氨酸受体表达的变化。
Temperature (Austin). 2014 Jul 1;1(1):57-65. doi: 10.4161/temp.29719. eCollection 2014 Apr-Jun.
2
Does heat acclimation improve exercise capacity at altitude? A cross-tolerance model.热适应能否提高在高原地区的运动能力？一种交叉耐受模型。
Int J Sports Med. 2014 Nov;35(12):975-81. doi: 10.1055/s-0034-1368724. Epub 2014 May 9.
3
Heat acclimation and performance in hypoxic conditions.
热适应与低氧条件下的表现
Aviat Space Environ Med. 2012 Jul;83(7):649-53. doi: 10.3357/asem.3241.2012.
4
Heat acclimation provides sustained improvement in functional recovery and attenuates apoptosis after traumatic brain injury.热适应可提供持续改善的功能恢复，并减轻创伤性脑损伤后的细胞凋亡。
J Cereb Blood Flow Metab. 2010 Mar;30(3):616-27. doi: 10.1038/jcbfm.2009.234. Epub 2009 Nov 11.
5
HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart.缺氧诱导因子-1α靶向通路通过热适应被激活，并有助于心脏的适应-缺血交叉耐受。
Physiol Genomics. 2005 Sep 21;23(1):79-88. doi: 10.1152/physiolgenomics.00279.2004. Epub 2005 Jul 26.
6
Behavioural and morphological outcome of mild cortical contusion trauma of the rat brain: influence of NMDA-receptor blockade.
Acta Neurochir (Wien). 1999;141(2):193-202. doi: 10.1007/s007010050286.