人体热疗诱导的过度通气的特征
Characteristics of hyperthermia-induced hyperventilation in humans.
作者信息
Tsuji Bun, Hayashi Keiji, Kondo Narihiko, Nishiyasu Takeshi
机构信息
Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba City, Japan; Department of Health Sciences, Prefectural University of Hiroshima, Hiroshima, Japan.
Junior College, University of Shizuoka , Shizuoka, Japan.
出版信息
Temperature (Austin). 2016 Feb 18;3(1):146-60. doi: 10.1080/23328940.2016.1143760. eCollection 2016 Jan-Mar.
In humans, hyperthermia leads to activation of a set of thermoregulatory responses that includes cutaneous vasodilation and sweating. Hyperthermia also increases ventilation in humans, as is observed in panting dogs, but the physiological significance and characteristics of the hyperventilatory response in humans remain unclear. The relative contribution of respiratory heat loss to total heat loss in a hot environment in humans is small, and this hyperventilation causes a concomitant reduction in arterial CO2 pressure (hypocapnia), which can cause cerebral hypoperfusion. Consequently, hyperventilation in humans may not contribute to the maintenance of physiological homeostasis (i.e., thermoregulation). To gain some insight into the physiological significance of hyperthermia-induced hyperventilation in humans, in this review, we discuss 1) the mechanisms underlying hyperthermia-induced hyperventilation, 2) the factors modulating this response, and 3) the physiological consequences of the response.
在人类中，体温过高会引发一系列体温调节反应，包括皮肤血管舒张和出汗。体温过高还会增加人类的通气量，这在喘气的狗身上也能观察到，但人类过度通气反应的生理意义和特征仍不清楚。在炎热环境中，呼吸散热对人体总散热的相对贡献较小，而且这种过度通气会导致动脉血二氧化碳压力随之降低（低碳酸血症），进而可能引起脑灌注不足。因此，人类的过度通气可能无助于维持生理稳态（即体温调节）。为了深入了解体温过高引起的人类过度通气的生理意义，在本综述中，我们讨论了：1）体温过高引起过度通气的潜在机制；2）调节这种反应的因素；3）该反应的生理后果。
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