Huang Xiaojun, Liu Zhening, Mwansisya Tumbwene E, Pu Weidan, Zhou Li, Liu Chang, Chen Xudong, Rohrbaugh Robert, Marienfeld Carla, Xue Zhimin, Liu Haihong
Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
State Key Laboratory of Medical Genetics, Central South University, Changsha, PR China.
J Magn Reson Imaging. 2017 Jan;45(1):157-166. doi: 10.1002/jmri.25322. Epub 2016 May 26.
To explore the acute effect of betel quid (BQ) use on functional network connectivity by comparing the global functional brain networks and their subsets before and immediately after BQ chewing.
Resting-state functional magnetic resonance imaging (fMRI) was performed in 27 healthy male participants before and just after chewing BQ on a 3.0T scanner with a gradient-echo echo planar imaging sequence. Independent component analysis (ICA) was used to determine components that represent the brain's functional networks and their spatial aspects of functional connectivity. A paired t-test was used for exploring the connectivity differences in each network before and after BQ chewing.
Sixteen networks were identified by ICA. Nine of them showed connectivity differences before and after BQ chewing (P < 0.05 false discovery rate corrected): (A) orbitofrontal, (B) left frontoparietal, (C) visual, (D) right frontoparietal, (E) anterior default mode, (F) medial frontal/anterior cingulate (G) frontotemporal, (H) occipital/parietal, (I) occipital/temporal/cerebellum. Moreover, networks A, B, C, D, G, H, and I showed increased connectivity, while networks E and F showed decreased connectivity in participants after BQ chewing compared to before chewing.
The acute effects of BQ use appear to actively alter functional connectivity of frontal and default networks that are known to play a key role in addictive behavior.
2 J. Magn. Reson. Imaging 2017;45:157-166.
通过比较咀嚼槟榔前后的全脑功能网络及其子集，探讨槟榔使用对功能网络连接性的急性影响。
27名健康男性参与者在3.0T扫描仪上，采用梯度回波平面回波成像序列，在咀嚼槟榔前和咀嚼后即刻进行静息态功能磁共振成像（fMRI）。独立成分分析（ICA）用于确定代表大脑功能网络及其功能连接空间方面的成分。采用配对t检验探讨咀嚼槟榔前后各网络连接性的差异。
ICA识别出16个网络。其中9个在咀嚼槟榔前后显示出连接性差异（P < 0.05，经错误发现率校正）：（A）眶额，（B）左侧额顶叶，（C）视觉，（D）右侧额顶叶，（E）前默认模式，（F）内侧额叶/前扣带回，（G）额颞叶，（H）枕叶/顶叶，（I）枕叶/颞叶/小脑。此外，与咀嚼前相比，咀嚼槟榔后的参与者中，网络A、B、C、D、G、H和I的连接性增加，而网络E和F的连接性降低。
使用槟榔的急性效应似乎会积极改变额叶和默认网络的功能连接，而这些网络已知在成瘾行为中起关键作用。
2 J. Magn. Reson. Imaging 2017;45:157 - 166。
