Hua Rongrong, Li Ping, Wang Xiaodong, Yang Jing, Zheng Pei, Niu Xinxin, Li Yan, An Yihua
Department of Cell Therapy, The General Hospital of Chinese People's Armed Police Forces, Beijing.
Department of Electrophysiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, P. R. China.
Pain Physician. 2016 May;19(4):E659-66.
Spinal cord injury (SCI) causes a high incidence of motor and sensory dysfunctions accompanied with neuropathic pain. No effective treatment is available. Both somatosensory evoked potential (SSEP) and neuropathic pain (NPP) are transmitted via myelinated large diameter fibers of deep sensory pathways. Here we aimed to evaluate whether SSEP can consistently and objectively assess transmission of deep sensory pathways, and to examine the effects of umbilical cord mesenchymal stem cell (UCMSC) transplantation on SSEP and NPP as assessed by the pain rating index (PRI) in a patient with a 2-year history of complete cervical SCI. We demonstrate that SSEP can directly reflect physiological function of myelinated large fibers in deep sensory pathway transmission (NPP is also transmitted by the same pathway). One year after UCMSC transplantation, the SSEP parameter, PRI, and clinical presentations of NPP significantly improved.
Spinal cord, neuropathic pain, somatosensory evoked potential, umbilical cord mesenchymal stem cells.
脊髓损伤（SCI）会导致运动和感觉功能障碍的高发生率，并伴有神经性疼痛。目前尚无有效的治疗方法。体感诱发电位（SSEP）和神经性疼痛（NPP）均通过深部感觉通路的有髓大直径纤维进行传导。在此，我们旨在评估SSEP是否能够持续、客观地评估深部感觉通路的传导情况，并通过疼痛评分指数（PRI）来检测脐带间充质干细胞（UCMSC）移植对一名有2年完全性颈髓SCI病史患者的SSEP和NPP的影响。我们证明，SSEP能够直接反映深部感觉通路传导中有髓大纤维的生理功能（NPP也通过相同通路传导）。UCMSC移植1年后，SSEP参数、PRI以及NPP的临床表现均有显著改善。
脊髓、神经性疼痛、体感诱发电位、脐带间充质干细胞。
