Matsuura Hiroki, Kimoto Sohei, Harada Izumi, Naemura Satoshi, Yamamuro Kazuhiko, Kishimoto Toshifumi
Department of Psychiatry, Tenri Hospital, Tenri, Japan.
Department of Psychiatry, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan.
BMC Psychiatry. 2016 May 26;16:161. doi: 10.1186/s12888-016-0874-x.
Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects.
We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms.
The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia.
抗精神病药物治疗可能会导致诸如白细胞减少症和中性粒细胞减少症等不良事件。尽管这些事件很少见，但它们代表着严重且危及生命的血液学副作用。
我们呈现了一名50岁患有分裂情感性障碍女性患者的病例研究。我们报告了一例在患有分裂情感性障碍的女性患者中由帕利哌酮缓释片（ER）引起的白细胞减少症和中性粒细胞减少症。启动碳酸锂治疗并降低丙戊酸剂量改善了观察到的白细胞减少症和中性粒细胞减少症。这种治疗并未影响精神症状。
帕利哌酮缓释片和丙戊酸联合使用会导致帕利哌酮缓释片血浆水平升高。碳酸锂成功用于治疗帕利哌酮缓释片引起的白细胞减少症和中性粒细胞减少症。
