Shin Han-Back, Yoon Do-Kun, Jung Joo-Young, Kim Moo-Sub, Suh Tae Suk
Department of Biomedical Engineering and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul 505, South Korea.
Department of Biomedical Engineering and Research Institute of Biomedical Engineering, College of Medicine, Catholic University of Korea, Seoul 505, South Korea.
Phys Med. 2016 Oct;32(10):1271-1275. doi: 10.1016/j.ejmp.2016.05.053. Epub 2016 May 24.
The purpose of this study was to verify acquisition feasibility of a single photon emission computed tomography image using prompt gamma rays for proton boron fusion therapy (PBFT) and to confirm an enhanced therapeutic effect of PBFT by comparison with conventional proton therapy without use of boron.
Monte Carlo simulation was performed to acquire reconstructed image during PBFT. We acquired percentage depth dose (PDD) of the proton beams in a water phantom, energy spectrum of the prompt gamma rays, and tomographic images, including the boron uptake region (BUR; target). The prompt gamma ray image was reconstructed using maximum likelihood expectation maximisation (MLEM) with 64 projection raw data. To verify the reconstructed image, both an image profile and contrast analysis according to the iteration number were conducted. In addition, the physical distance between two BURs in the region of interest of each BUR was measured.
The PDD of the proton beam from the water phantom including the BURs shows more efficient than that of conventional proton therapy on tumour region. A 719keV prompt gamma ray peak was clearly observed in the prompt gamma ray energy spectrum. The prompt gamma ray image was reconstructed successfully using 64 projections. Different image profiles including two BURs were acquired from the reconstructed image according to the iteration number.
We confirmed successful acquisition of a prompt gamma ray image during PBFT. In addition, the quantitative image analysis results showed relatively good performance for further study.
本研究的目的是验证使用瞬发伽马射线进行质子硼融合治疗（PBFT）时单光子发射计算机断层扫描图像的采集可行性，并通过与不使用硼的传统质子治疗进行比较，确认PBFT增强的治疗效果。
进行蒙特卡罗模拟以获取PBFT期间的重建图像。我们获取了水模体中质子束的百分深度剂量（PDD）、瞬发伽马射线的能谱以及断层图像，包括硼摄取区域（BUR；靶区）。使用具有64个投影原始数据的最大似然期望最大化（MLEM）算法重建瞬发伽马射线图像。为了验证重建图像，进行了图像轮廓分析和根据迭代次数的对比度分析。此外，测量了每个BUR感兴趣区域内两个BUR之间的物理距离。
包含BUR的水模体中质子束的PDD在肿瘤区域显示出比传统质子治疗更高的效率。在瞬发伽马射线能谱中清晰观察到719keV的瞬发伽马射线峰。使用64个投影成功重建了瞬发伽马射线图像。根据迭代次数从重建图像中获取了包括两个BUR的不同图像轮廓。
我们确认在PBFT期间成功采集到了瞬发伽马射线图像。此外，定量图像分析结果显示出相对较好的性能，可供进一步研究。
