膜联蛋白A1：使平衡向消退和修复转变。
Annexin A1: shifting the balance towards resolution and repair.
作者信息
Leoni Giovanna, Nusrat Asma
出版信息
Biol Chem. 2016 Oct 1;397(10):971-9. doi: 10.1515/hsz-2016-0180.
Abstract
Epithelial barriers play an important role in regulating mucosal homeostasis. Upon injury, the epithelium and immune cells orchestrate repair mechanisms that re-establish homeostasis. This process is highly regulated by protein and lipid mediators such as Annexin A1 (ANXA1). In this review, we focus on the pro-repair properties of ANXA1.
摘要
上皮屏障在调节黏膜稳态中发挥着重要作用。受伤后，上皮细胞和免疫细胞会协调修复机制以重新建立稳态。这一过程受到蛋白质和脂质介质如膜联蛋白A1（ANXA1）的高度调控。在本综述中，我们聚焦于ANXA1的促修复特性。
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本文引用的文献
1
The microenvironment of injured murine gut elicits a local pro-restitutive microbiota.
Nat Microbiol. 2016 Jan 27;1:15021. doi: 10.1038/nmicrobiol.2015.21.
2
Resolution of inflammation: a new therapeutic frontier.
Nat Rev Drug Discov. 2016 Aug;15(8):551-67. doi: 10.1038/nrd.2016.39. Epub 2016 Mar 29.
3
Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process.
Sci Rep. 2016 Mar 3;6:22586. doi: 10.1038/srep22586.
4
The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil.
Int Immunopharmacol. 2016 Mar;32:87-95. doi: 10.1016/j.intimp.2016.01.003. Epub 2016 Jan 21.
5
Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1.
J Immunol. 2016 Feb 15;196(4):1922-32. doi: 10.4049/jimmunol.1500886. Epub 2016 Jan 22.
6
Annexin A1 localization and its relevance to cancer.
Clin Sci (Lond). 2016 Feb;130(4):205-20. doi: 10.1042/CS20150415.
7
Specialized pro-resolving mediators: endogenous regulators of infection and inflammation.
Nat Rev Immunol. 2016 Jan;16(1):51-67. doi: 10.1038/nri.2015.4. Epub 2015 Dec 21.
8
Annexin A1 Deficiency does not Affect Myofiber Repair but Delays Regeneration of Injured Muscles.
Sci Rep. 2015 Dec 15;5:18246. doi: 10.1038/srep18246.
9
Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis.
Sci Transl Med. 2015 Nov 25;7(315):315ra190. doi: 10.1126/scitranslmed.aac5608.
10
Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1.
Science. 2015 Nov 20;350(6263):972-8. doi: 10.1126/science.aad0779. Epub 2015 Oct 29.
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