Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation (ZMBE), University of Münster, Von-Esmarch-Strasse 56, Münster, Germany.
Department of Life Sciences, Centre for Inflammation Research and Translational Medicine (CIRTM), Brunel University London, Uxbridge, UK.
Nat Commun. 2024 Feb 21;15(1):1574. doi: 10.1038/s41467-024-45954-0.
Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca levels. Through this they act as Ca-regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca-regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field.
钙结合蛋白（Annexins）是一类具有保守三维结构的细胞质蛋白，能够在细胞内钙离子浓度升高时与细胞膜上的酸性磷脂结合。通过这种方式，钙结合蛋白充当钙调节的膜结合模块，组织膜脂，促进细胞内的膜运输，但也具有细胞外活性。最近的发现强调了钙结合蛋白作为细胞和生物体应激的传感器和调节剂的作用，控制着哺乳动物的炎症反应、植物的环境应激以及细胞对质膜破裂的反应。在这里，我们描述了钙结合蛋白作为钙调节的膜结合模块的作用，这些模块能够感知和响应细胞应激，并分享我们对该领域未来研究方向的看法。
Zotero 插件
