Suresh Snophia, Mahendra Jaideep, Sudhakar Uma, Pradeep A R, Singh Gurdeep
Department of Periodontics, Thaimoogambigai Dental College, Chennai, Tamil Nadu, India.
Department of Periodontics, Meenakshiammal Dental College, Chennai, Tamil Nadu, India.
Indian J Dent Res. 2016 Mar-Apr;27(2):155-9. doi: 10.4103/0970-9290.183117.
Obesity represents the systemic condition capable of influencing the onset and progression of periodontal disease. Obesity is associated with oxidative stress. Plasma level of reactive oxidative metabolites (ROMs) is measured as an indicator of oxidative stress in the body. The aim of this study is to assess and compare the plasma ROM levels in obese subjects with healthy and inflammatory periodontal status.
Sixty subjects selected were grouped as 15 obese or overweight subjects with generalized chronic periodontitis, 15 obese or overweight subjects with generalized chronic gingivitis, 15 obese or overweight subjects with healthy periodontium, and 15 nonobese and healthy periodontium. The clinical periodontal parameters such as plaque index, gingival index, probing pocket depth, and clinical attachment level were measured. Blood samples were obtained to measure the plasma levels of ROM.
In this study, obese subjects with chronic periodontitis (Group I) had mean plasma ROM levels (442.3 ± 15.65 Carratelli unit [CARR U]) showing 100% subjects with high oxidative stress. Obese subjects with chronic gingivitis (Group II) had mean plasma ROM levels (358.7 ± 20.61 CARR U) indicating 86.7% subjects with oxidative stress. Obese subjects with healthy periodontium (Group III) had 46.7% subjects with slight oxidative stress, and the mean ROM level was 320.2 ± 17.57. Nonobese subjects with healthy periodontium (Group IV) had 80% of subjects with normal oxidative stress and the mean plasma ROM level was 296.9 ± 20.35 CARR U. The intra- and inter-group comparison showed significant difference (P < 0.001). From our study, we report that obese subjects with periodontitis have more oxidative stress compared to obese subjects with healthy periodontium.
肥胖是一种能够影响牙周疾病发生和发展的全身性疾病。肥胖与氧化应激相关。活性氧化代谢产物（ROMs）的血浆水平可作为体内氧化应激的指标进行测量。本研究旨在评估和比较肥胖受试者在健康和炎症性牙周状态下的血浆ROM水平。
选取60名受试者，分为15名患有广泛性慢性牙周炎的肥胖或超重受试者、15名患有广泛性慢性牙龈炎的肥胖或超重受试者、15名牙周健康的肥胖或超重受试者以及15名非肥胖且牙周健康的受试者。测量菌斑指数、牙龈指数、探诊深度和临床附着水平等临床牙周参数。采集血样以测量血浆ROM水平。
在本研究中，患有慢性牙周炎的肥胖受试者（第一组）的血浆ROM平均水平为（442.3 ± 15.65卡拉泰利单位[CARR U]），表明100%的受试者存在高氧化应激。患有慢性牙龈炎的肥胖受试者（第二组）的血浆ROM平均水平为（358.7 ± 20.61 CARR U），表明86.7% 的受试者存在氧化应激。牙周健康的肥胖受试者（第三组）有46.7% 的受试者存在轻度氧化应激，ROM平均水平为320.2 ± 17.57。非肥胖且牙周健康的受试者（第四组）有80% 的受试者氧化应激正常，血浆ROM平均水平为296.9 ± 20.35 CARR U。组内和组间比较显示差异有统计学意义（P < 0.001）。根据我们的研究，我们报告患有牙周炎的肥胖受试者比牙周健康的肥胖受试者具有更多氧化应激。
