Kim H, Oh K H
Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United States.
Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United States.
Int Rev Neurobiol. 2016;128:127-61. doi: 10.1016/bs.irn.2016.03.003. Epub 2016 Mar 28.
The large conductance, voltage- and calcium-dependent potassium BK channel, also termed BKCa, Maxi-K, KCa1.1, or SLO1, regulates a wide array of key biological processes that are mediated by calcium ions. This broad regulatory function of BK channels requires the interactions of BK channels with diverse sets of proteins that have different molecular or cellular functions. Proteins that interact with BK channels range from the auxiliary subunits of BK channels to cytoskeletal proteins responsible for BK channel trafficking and localization. Furthermore, depending on cellular contexts, BK channels interact with proteins modifying channel properties, and with proteins that allow cell-specific responses. In this chapter, we review some of the relevant studies investigating the protein interaction network of BK channels with a focus on the biological roles of the interaction.
大电导、电压和钙依赖性钾通道（BK通道），也被称为BKCa、Maxi-K、KCa1.1或SLO1，调节着由钙离子介导的一系列关键生物学过程。BK通道的这种广泛调节功能需要BK通道与具有不同分子或细胞功能的多种蛋白质相互作用。与BK通道相互作用的蛋白质范围从BK通道的辅助亚基到负责BK通道运输和定位的细胞骨架蛋白。此外，根据细胞环境，BK通道与修饰通道特性的蛋白质以及允许细胞特异性反应的蛋白质相互作用。在本章中，我们回顾了一些相关研究，这些研究调查了BK通道的蛋白质相互作用网络，重点关注相互作用的生物学作用。
