Fortes Marina R S, Nguyen Loan To, Porto Neto Laercio R, Reverter Antonio, Moore Stephen S, Lehnert Sigrid A, Thomas Milton G
The University of Queensland, School of Chemistry and Molecular Bioscience, Brisbane, Qld, Australia.
The University of Queensland, School of Chemistry and Molecular Bioscience, Brisbane, Qld, Australia.
Theriogenology. 2016 Jul 1;86(1):333-9. doi: 10.1016/j.theriogenology.2016.04.046. Epub 2016 Apr 22.
Puberty onset is a multifactorial process influenced by genetic determinants and environmental conditions, especially nutritional status. Genes, genetic variations, and regulatory networks compose the molecular basis of achieving puberty. In this article, we reviewed the discovery of multiple polymorphisms and genes associated with heifer puberty phenotypes and discuss the opportunities to use this evolving knowledge of genetic determinants for breeding early pubertal Bos indicus-influenced cattle. The discovery of polymorphisms and genes was mainly achieved through candidate gene studies, quantitative trait loci analyses, genome-wide association studies, and recently, global gene expression studies (transcriptome). These studies are recapitulated and summarized in the current review.
青春期启动是一个受遗传因素和环境条件（尤其是营养状况）影响的多因素过程。基因、基因变异和调控网络构成了进入青春期的分子基础。在本文中，我们回顾了与小母牛青春期表型相关的多个多态性和基因的发现，并讨论了利用这一不断发展的遗传决定因素知识来培育早熟的婆罗门牛影响的牛的机会。多态性和基因的发现主要通过候选基因研究、数量性状位点分析、全基因组关联研究以及最近的全基因表达研究（转录组学）来实现。这些研究在当前综述中进行了概括和总结。
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