Anastasopoulou Stavroula, Lindefeldt Marie, Bartocci Marco, Wickström Ronny
Neuropediatric Unit, Dept of Women's and Children's Health, Karolinska Institutet, Sweden.
Neuropediatric Unit, Dept of Women's and Children's Health, Karolinska Institutet, Sweden.
Eur J Paediatr Neurol. 2016 Sep;20(5):754-7. doi: 10.1016/j.ejpn.2016.05.005. Epub 2016 May 13.
Acute inflammatory demyelinating polyneuropathy (AIDP), also known as Guillain-Barré syndrome, is an immune-mediated polyneuropathy usually triggered by infections or vaccinations. In childhood AIDP is commonly described after the first year of life. Here, we present a case of a newborn infant with AIDP manifestation directly after delivery.
A newborn girl with a healthy mother, without known exposure to immunomodulating factors, was admitted to the neuropediatric department due to ascending hypotonia, weakness, pain and areflexia in the lower extremities. The clinical presentation, laboratory and neurophysiological studies supported the diagnosis of AIDP. The infant showed first signs of clinical improvement following administration of intravenous immunoglobulin and her recovery was complete at one year.
AIDP should be considered as a differential diagnosis in ascending hypotonia also in the neonatal period.
急性炎症性脱髓鞘性多发性神经病（AIDP），也称为吉兰-巴雷综合征，是一种通常由感染或疫苗接种引发的免疫介导性多发性神经病。儿童期AIDP通常在出生后第一年被描述。在此，我们报告一例新生儿在出生后直接出现AIDP表现的病例。
一名母亲健康、无已知免疫调节因子接触史的新生女婴因下肢进行性肌张力减退、无力、疼痛和腱反射消失入住神经儿科。临床表现、实验室检查和神经生理学研究支持AIDP的诊断。婴儿在静脉注射免疫球蛋白后首次出现临床改善迹象，一年时完全康复。
在新生儿期，进行性肌张力减退时也应考虑AIDP作为鉴别诊断。
