Manneh Ray, Castellano Daniel, Caso Oscar, Loinaz Carmelo, Jiménez Jesús, Estenoz Juana, Calatayud Maria, Sepúlveda Juan M, García-Carbonero Rocio
Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Department of General Surgery, Hospital Universitario 12 de Octubre, Madrid, Spain.
Case Rep Oncol. 2016 Apr 27;9(1):255-61. doi: 10.1159/000445940. eCollection 2016 Jan-Apr.
Treatment of metastatic gastric neuroendocrine tumours (NETs) is challenging. In oligometastatic cases, surgical resection is recommended whenever possible. Somatostatin analogues have been used to decrease gastrin levels, and available evidence suggests that these drugs can also reduce recurrences. Here we present a highly unusual case involving a patient with a well-differentiated grade 2, type 3 gastric NET with exclusive metastatic bilateral ovarian involvement. To our knowledge, this is the first such case reported in the literature, as the cause of ovarian involvement is usually due to local invasion rather than metastasis. We believe this case is of interest not only due to the unusual presentation, but also because it makes us consider adjuvant treatment with somatostatin analogues in patients with low-grade tumours and a positive postoperative octreoscan.
转移性胃神经内分泌肿瘤（NETs）的治疗具有挑战性。在寡转移病例中，建议尽可能进行手术切除。生长抑素类似物已被用于降低胃泌素水平，现有证据表明这些药物还可减少复发。在此，我们报告一例极为罕见的病例，患者为高分化2级、3型胃神经内分泌肿瘤，仅双侧卵巢发生转移。据我们所知，这是文献中报道的首例此类病例，因为卵巢受累通常是由于局部侵犯而非转移所致。我们认为该病例不仅因其不寻常的表现而值得关注，还因为它促使我们考虑对低级别肿瘤且术后奥曲肽扫描呈阳性的患者使用生长抑素类似物进行辅助治疗。
