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肛管黏液腺癌切除术后的mFOLFOX6化疗

mFOLFOX6 Chemotherapy after Resection of Anal Canal Mucinous Adenocarcinoma.

作者信息

Matsunaga Mototsugu, Miwa Keisuke, Oka Yosuke, Nagasu Sachiko, Sakaue Takahiko, Fukahori Masaru, Ushijima Tomoyuki, Akagi Yoshito

机构信息

Multidisciplinary Treatment Cancer Center, Kurume University Hospital, Fukuoka, Japan.

Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan.

出版信息

Case Rep Oncol. 2016 Apr 29;9(1):280-4. doi: 10.1159/000446066. eCollection 2016 Jan-Apr.

DOI:10.1159/000446066
PMID:27239184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4881242/
Abstract

Because of their rarity, there are no clear guidelines for the treatment of anal carcinomas; such tumors are normally subjected to the same modalities as recommended for rectal cancer. We report a patient with anal canal mucinous adenocarcinoma, with metastases in the pararectal and right inguinal lymph nodes, who was treated with abdominoperineal resection followed by mFOLFOX6 chemotherapy for 6 months (12 cycles). The patient has remained recurrence-free thus far, approximately 2 years since the surgery. As the optimal treatments for anal carcinomas have not been fully elucidated, we present this case to highlight a possible course of action for such patients that appears to be effective and promising.

摘要

由于肛管癌较为罕见,目前尚无明确的治疗指南;此类肿瘤通常采用与直肠癌相同的治疗方式。我们报告一例肛管黏液腺癌患者,其直肠旁和右侧腹股沟淋巴结有转移,接受了腹会阴联合切除术,随后接受mFOLFOX6化疗6个月(12个周期)。自手术以来约2年,该患者至今未复发。由于肛管癌的最佳治疗方法尚未完全阐明,我们呈现此病例以突出一种对此类患者可能有效的、有前景的治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445c/4881242/dbec8f6bb7fc/cro-0009-0280-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445c/4881242/5578d4731f9b/cro-0009-0280-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445c/4881242/c6542aa1d7f3/cro-0009-0280-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445c/4881242/dbec8f6bb7fc/cro-0009-0280-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445c/4881242/5578d4731f9b/cro-0009-0280-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445c/4881242/c6542aa1d7f3/cro-0009-0280-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/445c/4881242/dbec8f6bb7fc/cro-0009-0280-g03.jpg

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本文引用的文献

1
Review on adjuvant chemotherapy for rectal cancer - why do treatment guidelines differ so much?直肠癌辅助化疗综述——为何治疗指南差异如此之大?
Acta Oncol. 2015 Apr;54(4):437-46. doi: 10.3109/0284186X.2014.993768. Epub 2015 Jan 19.
2
Oxaliplatin, fluorouracil, and leucovorin with or without cetuximab in patients with resected stage III colon cancer (PETACC-8): an open-label, randomised phase 3 trial.奥沙利铂、氟尿嘧啶和亚叶酸与或不与西妥昔单抗联合用于 III 期结肠癌切除术后患者(PETACC-8):一项开放标签、随机、III 期临床试验。
Lancet Oncol. 2014 Jul;15(8):862-73. doi: 10.1016/S1470-2045(14)70227-X. Epub 2014 Jun 11.
3
Cancer statistics, 2013.
癌症统计数据,2013 年。
CA Cancer J Clin. 2013 Jan;63(1):11-30. doi: 10.3322/caac.21166. Epub 2013 Jan 17.
4
Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08.评估贝伐单抗在 II 期和 III 期结肠癌中的 III 期临床试验:NSABP 方案 C-08 的结果。
J Clin Oncol. 2011 Jan 1;29(1):11-6. doi: 10.1200/JCO.2010.30.0855. Epub 2010 Oct 12.
5
Final results of randomized trials by the National Surgical Adjuvant Study of Colorectal Cancer (NSAS-CC).国家结直肠肿瘤外科辅助研究(NSAS-CC)的随机试验最终结果。
Cancer Chemother Pharmacol. 2011 Mar;67(3):587-96. doi: 10.1007/s00280-010-1358-1. Epub 2010 May 19.
6
NCCN clinical practice guidelines in oncology. Anal carcinoma.美国国立综合癌症网络(NCCN)肿瘤学临床实践指南。肛管癌
J Natl Compr Canc Netw. 2010 Jan;8(1):106-20. doi: 10.6004/jnccn.2010.0007.
7
NCCN Clinical Practice Guidelines in Oncology: rectal cancer.美国国立综合癌症网络(NCCN)肿瘤学临床实践指南:直肠癌
J Natl Compr Canc Netw. 2009 Sep;7(8):838-81. doi: 10.6004/jnccn.2009.0057.
8
NCCN Clinical Practice Guidelines in Oncology: colon cancer.美国国立综合癌症网络(NCCN)肿瘤学临床实践指南:结肠癌
J Natl Compr Canc Netw. 2009 Sep;7(8):778-831. doi: 10.6004/jnccn.2009.0056.
9
Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial.在MOSAIC试验中,奥沙利铂、氟尿嘧啶和亚叶酸作为II期或III期结肠癌辅助治疗可提高总生存率。
J Clin Oncol. 2009 Jul 1;27(19):3109-16. doi: 10.1200/JCO.2008.20.6771. Epub 2009 May 18.
10
Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine.使用口服氟嘧啶S-1对胃癌进行辅助化疗。
N Engl J Med. 2007 Nov 1;357(18):1810-20. doi: 10.1056/NEJMoa072252.