Krishna V R, Fouant M M, Bradley S G
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond 23298-0110.
J Parasitol. 1989 Jun;75(3):405-10.
Female B6C3F1 mice treated with 25 mg/kg pyran intravenously (i.v.) on days -4 and -3 were more susceptible to nonlethal Plasmodium yoelii 17XNL or lethal Plasmodium berghei ATCC-30090 than untreated mice or mice treated intraperitoneally (i.p.). Female B6C3F1 mice treated with pyran i.p. displayed enhanced resistance to Listeria monocytogenes as compared to untreated mice or mice given pyran i.v. Peritoneal exudate cells (PEC) primed by pyran i.p. possessed enhanced ability to kill Listeria but impaired ability to destroy Plasmodium. Phagocytosis of Covaspheres by PEC was greater for mice given pyran i.p. than those given pyran i.v. Chemiluminescence evoked by zymosan was less for PEC from mice given pyran i.v. than for those from untreated mice or those given pyran i.p. Chemiluminescence was greater for adherent splenocytes from mice treated with pyran i.p. than for those from untreated mice or those from mice treated i.v. Pyran administered i.v. is less effective in modulating the host immune response than pyran administered i.p. Immunomodulatory agents such as pyran have adverse as well as beneficial effects depending upon the route of administration.
在第-4天和-3天静脉注射（i.v.）25mg/kg吡喃的雌性B6C3F1小鼠比未处理的小鼠或腹腔注射（i.p.）吡喃的小鼠更容易感染非致死性约氏疟原虫17XNL或致死性伯氏疟原虫ATCC - 30090。与未处理的小鼠或静脉注射吡喃的小鼠相比，腹腔注射吡喃的雌性B6C3F1小鼠对单核细胞增生李斯特菌表现出更强的抵抗力。腹腔注射吡喃引发的腹膜渗出细胞（PEC）具有增强的杀灭李斯特菌的能力，但破坏疟原虫的能力受损。腹腔注射吡喃的小鼠的PEC对共聚物微球的吞噬作用大于静脉注射吡喃的小鼠。静脉注射吡喃的小鼠的PEC由酵母聚糖引发的化学发光比未处理的小鼠或腹腔注射吡喃的小鼠的PEC少。腹腔注射吡喃的小鼠的贴壁脾细胞的化学发光比未处理的小鼠或静脉注射吡喃的小鼠的贴壁脾细胞强。静脉注射吡喃在调节宿主免疫反应方面比腹腔注射吡喃效果差。像吡喃这样的免疫调节剂根据给药途径既有不良影响也有有益影响。
