Irving Greg, Holden John
Institute of Public Health, University of Cambridge, Cambridge, CB2 OSR, UK.
General Practitioner, Garswood Surgery, St. Helens, Lancashire, WN4 0XD, UK.
F1000Res. 2016 Feb 26;5:222. doi: 10.12688/f1000research.8114.3. eCollection 2016.
Trust in scientific research is diminished by evidence that data are being manipulated. Outcome switching, data dredging and selective publication are some of the problems that undermine the integrity of published research. Methods for using blockchain to provide proof of pre-specified endpoints in clinical trial protocols were first reported by Carlisle. We wished to empirically test such an approach using a clinical trial protocol where outcome switching has previously been reported. Here we confirm the use of blockchain as a low cost, independently verifiable method to audit and confirm the reliability of scientific studies.
数据被操纵的证据削弱了对科学研究的信任。结果切换、数据挖掘和选择性发表是一些破坏已发表研究完整性的问题。卡莱尔首次报道了使用区块链为临床试验方案中的预先指定终点提供证明的方法。我们希望使用一个此前曾报道过结果切换的临床试验方案，对这种方法进行实证检验。在此，我们证实了区块链可作为一种低成本、可独立验证的方法，用于审核和确认科学研究的可靠性。
