I-125 敷贴放疗治疗伴有眼球外突出肿块的睫状体脉络膜黑色素瘤后发生的进行性巩膜坏死
Progressive Scleral Necrosis following I-125 Plaque Radiotherapy for Ciliochoroidal Melanoma with Protruding Extraocular Mass.
作者信息
Hill Jordan R, Corrêa Zélia M
机构信息
Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
出版信息
Ocul Oncol Pathol. 2016 Apr;2(3):136-9. doi: 10.1159/000441660. Epub 2015 Nov 20.
Abstract
PURPOSE
The aim of this study was to describe the side effects of I-125 brachytherapy in the treatment of uveal melanoma.
METHODS
This study was conducted as a case report.
RESULTS
We report a case of scleral necrosis and protruding episcleral mass following the treatment of uveal melanoma with I-125 brachytherapy.
CONCLUSIONS
Scleral necrosis after plaque radiotherapy can clinically simulate tumor recurrence with extraocular extension. The management of uveal melanoma requires a careful clinical follow-up, weighing the implications of treatment morbidity and mortality.
摘要
目的
本研究旨在描述碘-125近距离放射治疗葡萄膜黑色素瘤的副作用。
方法
本研究以病例报告形式开展。
结果
我们报告了1例在用碘-125近距离放射治疗葡萄膜黑色素瘤后出现巩膜坏死和巩膜外肿块突出的病例。
结论
敷贴放疗后发生的巩膜坏死在临床上可能类似于伴有眼外扩展的肿瘤复发。葡萄膜黑色素瘤的治疗需要仔细的临床随访，权衡治疗的发病率和死亡率影响。
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本文引用的文献
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Scleral necrosis after radiation therapy for uveal melanomas: report of 23 cases.葡萄膜黑色素瘤放射治疗后巩膜坏死：23例报告
Graefes Arch Clin Exp Ophthalmol. 2008 Dec;246(12):1731-6. doi: 10.1007/s00417-008-0920-6. Epub 2008 Sep 3.
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The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognostic factors: COMS report No. 28.125碘近距离放射治疗脉络膜黑色素瘤的COMS随机试验：V. 12年死亡率及预后因素：COMS报告第28号
Arch Ophthalmol. 2006 Dec;124(12):1684-93. doi: 10.1001/archopht.124.12.1684.
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