Thanoo B C, Jayakrishnan A
Division of Polymer Chemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
J Microencapsul. 1989 Apr-Jun;6(2):233-44. doi: 10.3109/02652048909098026.
Spherical, hydrophilic microspheres prepared from crosslinked poly(methyl methacrylate) (PMMA) by alkaline hydrolysis have been made radiopaque by impregnating with barium sulphate by the precipitation technique. Microspheres having carboxyl functions as their alkali metal salt were swollen in sodium sulphate solution and barium sulphate entrapment was effected by treating with barium chloride solution. The swelling characteristics of the microspheres could be controlled by acidification and further by anhydride formation thereby trapping the barium sulphate firmly inside the microspheres. Barium sulphate loading of up to 70 wt-per cent could be achieved by this technique. These microspheres have been found to possess excellent X-ray contrast properties and may find application as particulate emboli in endovascular embolization.
通过碱性水解由交联聚甲基丙烯酸甲酯（PMMA）制备的球形亲水性微球，已通过沉淀技术用硫酸钡浸渍使其具有射线不透性。具有羧基作为其碱金属盐的微球在硫酸钠溶液中溶胀，并通过用氯化钡溶液处理实现硫酸钡截留。微球的溶胀特性可以通过酸化进一步通过酸酐形成来控制，从而将硫酸钡牢固地截留在微球内部。通过该技术可以实现高达70重量百分比的硫酸钡负载量。已发现这些微球具有优异的X射线造影特性，并可能作为颗粒栓塞剂用于血管内栓塞。
