Fehri B, Aiache J M, Boukef K
J Pharm Belg. 1989 Jan-Feb;44(1):5-10.
The aim of this study is to compare the bioavailability of acetylsalicylic acid administered rectally in suppositories form and orally in tablets form to the rabbit. Acetylsalicylic acid was given to 8 males rabbits rectally and orally in a balanced crossover design with 15 days of interval between each study. In blood samples, acetylsalicylic acid is determined by Trinder's method. It has been established that the rectal route has a faster absorption than the oral route however it displayed a more intense first pass effect than that of the oral route.
本研究的目的是比较以栓剂形式直肠给药和以片剂形式口服给药的乙酰水杨酸对家兔的生物利用度。采用平衡交叉设计，给8只雄性家兔分别直肠给药和口服给药，每次研究间隔15天。采用Trinder法测定血样中的乙酰水杨酸。已证实直肠给药途径的吸收比口服给药途径更快，然而其首过效应比口服给药途径更强烈。
