Wang Shang-Lin, Lee Jih-Jong, Liao Albert Taiching
National Taiwan University Veterinary Hospital, College of Bioresources and Agriculture, National Taiwan University, Taipei, 10672, Taiwan; Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, 10617, Taiwan.
Graduate Institute of Veterinary Clinical Science, School of Veterinary Medicine, National Taiwan University, Taipei, 10617, Taiwan; Animal Cancer Center, College of Bioresources and Agriculture, National Taiwan University, Taipei, 10617, Taiwan.
Vet J. 2016 Jul;213:87-9. doi: 10.1016/j.tvjl.2016.04.013. Epub 2016 Apr 29.
Combination chemotherapy, using cyclophosphamide, hydroxydaunorubicin, vincristine and prednisolone (CHOP), is the most commonly used treatment for canine lymphoma. Most affected dogs respond during the initial stages of chemotherapy, but many relapse. The aim of this study was to evaluate the relationship between the use of specific chemotherapy drugs and clinical relapse, using the modified Madison-Wisconsin, 25 week chemotherapy protocol. Forty-one of 68 dogs affected with multicentric lymphoma relapsed during the treatment period. Relapse occurred more frequently after the administration of cyclophosphamide (n = 24; P < 0.01), compared with vincristine (n = 9) or doxorubicin (n = 5). Therefore, the therapeutic outcome of traditional CHOP-based chemotherapy might be improved by replacing cyclophosphamide with other cytotoxic drugs.
使用环磷酰胺、羟基柔红霉素、长春新碱和泼尼松龙（CHOP）的联合化疗是犬淋巴瘤最常用的治疗方法。大多数患病犬在化疗初期有反应，但许多会复发。本研究的目的是使用改良的麦迪逊-威斯康星25周化疗方案，评估特定化疗药物的使用与临床复发之间的关系。68只患有多中心淋巴瘤的犬中有41只在治疗期间复发。与长春新碱（n = 9）或阿霉素（n = 5）相比，环磷酰胺给药后复发更频繁（n = 24；P < 0.01）。因此，用其他细胞毒性药物替代环磷酰胺可能会改善基于传统CHOP化疗的治疗效果。
