利用亚硝酸水溶液将吩噻嗪盐方便地氧化为其亚砜。
Convenient oxidation of phenothiazine salts to their sulfoxides with aqueous nitrous acid.
作者信息
Owens M L, Juenge E C, Poklis A
机构信息
St. Louis University, MO.
出版信息
J Pharm Sci. 1989 Apr;78(4):334-6. doi: 10.1002/jps.2600780415.
PMID:2724098
Abstract
A simple method is reported for the preparation of gram quantities of phenothiazine sulfoxides by aqueous nitrous acid oxidation of phenothiazines at room temperature. The chiral levomepromazine gave rise to diastereoisomeric products analogous to those reported for thioridazine sulfoxidation.
摘要
据报道，一种简单的方法可用于在室温下通过亚硝酸水溶液氧化吩噻嗪来制备克级量的吩噻嗪亚砜。手性左美丙嗪产生的非对映异构体产物类似于报道的硫利达嗪亚砜化反应所产生的产物。
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