Slagor Rebekka Michaelsen, La Cour Morten, Bonde Jens Peter
Department of Occupational and Environmental Medicine, Frederiksberg Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
Scand J Work Environ Health. 2016 Sep 1;42(5):447-53. doi: 10.5271/sjweh.3572. Epub 2016 May 31.
There are indications that solar ultraviolet radiation (UVR) increases the risk of cataract, but there is only circumstantial evidence that metal welding, an important occupational source of UVR exposure, is a risk factor. The objective of this study is to unravel if metal welding increases the risk of cataract.
We compared the risk of being diagnosed with cataract from 1987-2012 in a historic cohort of 4288 male metal arc welders against a reference group comprised of Danish skilled and unskilled male workers with similar age distribution. For the welders' cohort, information on welding was collected from questionnaires and, for both cohorts, information about cataract diagnosis and operation was gathered from Danish national registers. Using Cox regression analysis, the hazard ratio (HR) for cataract diagnosis and/or operation was calculated in the follow-up period adjusted for baseline data regarding age, diabetes, and social group.
There were 266 welders and 29 007 referents with a diagnosis and/or operation for cataract. The unadjusted HR for cataract comparing ever-welders with referents was 1.07 [95% confidence interval (95% CI) 0.95-1.21] and the adjusted HR was 1.08 (95% CI 0.95-1.22). Age and diabetes were as expected strong risk factors.
We found no increased risk of developing cataract among Danish metal welders who worked with arc welding from 1950-1985. This may be attributed to the effectiveness of personal safety equipment.
有迹象表明太阳紫外线辐射(UVR)会增加患白内障的风险,但仅有间接证据表明金属焊接(UVR暴露的一个重要职业来源)是一个风险因素。本研究的目的是弄清楚金属焊接是否会增加患白内障的风险。
我们比较了1987年至2012年期间4288名男性金属电弧焊工的历史队列中被诊断为白内障的风险,对照组为年龄分布相似的丹麦熟练和非熟练男性工人组成的参考组。对于焊工队列,通过问卷收集焊接信息,对于两个队列,从丹麦国家登记处收集有关白内障诊断和手术的信息。使用Cox回归分析,计算随访期间白内障诊断和/或手术的风险比(HR),并根据年龄、糖尿病和社会群体的基线数据进行调整。
有266名焊工和29007名对照者被诊断为白内障和/或接受了白内障手术。将曾经的焊工与对照者相比,白内障的未调整HR为1.07 [95%置信区间(95%CI)0.95 - 1.21],调整后的HR为1.08(95%CI 0.95 - 1.22)。年龄和糖尿病如预期的那样是强烈的风险因素。
我们发现,1950年至1985年从事电弧焊接的丹麦金属焊工患白内障的风险没有增加。这可能归因于个人安全设备的有效性。