老挝人民民主共和国乙肝病毒母婴传播率高。
HIGH RATE OF HEPATITIS B VIRUS MOTHER-TO-CHILD TRANSMISSION IN LAO PEOPLE'S DEMOCRATIC REPUBLIC.
作者信息
Jutavijittum Prapan, Yousukh Amnat, Saysanasongkham Bounnack, Samountry Bounthome, Samountry Khamtim, Toriyama Kan, Tokuda Masaaki, Yoneyama Hirohito, Masaki Tsutomu
出版信息
Southeast Asian J Trop Med Public Health. 2016 Mar;47(2):214-8.
Hepatitis B virus infection is endemic in Lao People's Democratic Republic (PDR). Among 3,000 pregnant women attending an antenatal clinic at Mother and Child Hospital in Vientiane, Lao PDR, 5.8% were HBsAg positive by a rapid test. Among serum samples of 47 infants aged 9-12 months born to HBsAg-positive mothers, 38% were anti-HBs negative. Percent anti-HBs negative children is significantly higher in those born to HBeAg positive mothers than in those born to HBeAg negative mothers (60% vs 25%, p < 0.05). Out of 47 HBsAg-positive mothers, 10 had infants who were HBsAg positive. None of the infants born to HBsAg negative mothers became HBsAg positive but 10/19 (52.6%) of infants born to HBeAg positive mothers became HBsAg positive. This high rate of mother-to-child transmission of HBV in an endemic country is of concern and indicates that routine vaccination program for Lao infants needs strengthening.
乙型肝炎病毒感染在老挝人民民主共和国呈地方性流行。在老挝万象妇幼医院产前诊所就诊的3000名孕妇中，快速检测显示5.8%的孕妇乙肝表面抗原（HBsAg）呈阳性。在47名母亲为HBsAg阳性的9至12个月大婴儿的血清样本中，38%的婴儿乙肝表面抗体（anti-HBs）呈阴性。母亲乙肝e抗原（HBeAg）阳性的婴儿中anti-HBs阴性的比例显著高于HBeAg阴性母亲所生婴儿（60%对25%，p<0.05）。在47名HBsAg阳性母亲中，有10名母亲的婴儿HBsAg呈阳性。HBsAg阴性母亲所生婴儿无一例HBsAg呈阳性，但HBeAg阳性母亲所生婴儿中有10/19（52.6%）的婴儿HBsAg呈阳性。在一个地方性流行国家，如此高的乙肝母婴传播率令人担忧，这表明老挝婴儿的常规疫苗接种计划需要加强。
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