通过蛋白激酶 A（PKA）实现不依赖羟化的 HIF-1α 稳定：缺氧信号转导的新范例。
Hydroxylation-independent HIF-1α stabilization through PKA: A new paradigm for hypoxia signaling.
机构信息
Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA. Mucosal Inflammation Program, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO, USA. Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.
出版信息
Sci Signal. 2016 May 31;9(430):fs11. doi: 10.1126/scisignal.aaf4630.
In this issue of Science Signaling, Bullen et al demonstrate that protein kinase A (PKA) phosphorylates and stimulates the transcriptional activity of hypoxia-inducible transcription factor-1α (HIF-1α). This finding may have implications in diseases processes that occur at the interface of hypoxia and inflammation, where HIF-1α stabilization can function to dampen hypoxia-driven inflammation.
在本期《科学信号》中，布伦等人表明蛋白激酶 A（PKA）磷酸化并刺激缺氧诱导因子-1α（HIF-1α）的转录活性。这一发现可能对发生在缺氧和炎症交界处的疾病过程具有意义，在这些过程中，HIF-1α的稳定可以起到抑制缺氧驱动的炎症的作用。
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