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在BAR处连接:寡聚化与F-BAR蛋白功能

Linking up at the BAR: Oligomerization and F-BAR protein function.

作者信息

McDonald Nathan A, Gould Kathleen L

机构信息

a Department of Cell and Developmental Biology , Vanderbilt University , Nashville , TN , USA.

出版信息

Cell Cycle. 2016 Aug 2;15(15):1977-85. doi: 10.1080/15384101.2016.1190893. Epub 2016 May 31.

Abstract

As cells grow, move, and divide, they must reorganize and rearrange their membranes and cytoskeleton. The F-BAR protein family links cellular membranes with actin cytoskeletal rearrangements in processes including endocytosis, cytokinesis, and cell motility. Here we review emerging information on mechanisms of F-BAR domain oligomerization and membrane binding, and how these activities are coordinated with additional domains to accomplish scaffolding and signaling functions.

摘要

随着细胞的生长、移动和分裂,它们必须重新组织和排列其细胞膜和细胞骨架。F-BAR蛋白家族在包括内吞作用、胞质分裂和细胞运动等过程中,将细胞膜与肌动蛋白细胞骨架重排联系起来。在这里,我们综述了关于F-BAR结构域寡聚化和膜结合机制的新信息,以及这些活性如何与其他结构域协同作用以完成支架和信号功能。

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